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Chapter 110 Coagulation Disorders (Part 10) docx

Chapter 110. Coagulation Disorders (Part 10) docx

Chapter 110. Coagulation Disorders (Part 10) docx

... injection) to improve hemostasis. Table 110- 3 Coagulation Disorders and Hemostasis in Liver Disease Chapter 110. Coagulation Disorders (Part 10) Coagulation Disorders Associated with Liver Failure ... Decreased synthesis of coagulation inhibitors: protein C, protein S, antithrombin Hepatocyte failure Vitamin K deficiency (protein C, protein S) Failure to clear activated coagulation proteins ... abnormalities secondary to underlying liver disease further promote the occurrence of hemorrhage (Table 110- 3). Dysfibrinogenemia is a relatively common finding in patients with liver disease due to...
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Chapter 110. Coagulation Disorders (Part 1) pot

Chapter 110. Coagulation Disorders (Part 1) pot

... 11–14 d Chapter 110. Coagulation Disorders (Part 1) Harrison's Internal Medicine > Chapter 110. Coagulation Disorders Coagulation Disorders: Introduction Deficiencies of coagulation ... bleeding disorders due to deficiencies of other factors, including FII (prothrombin), FV, FVII, FX, FXI, FXIII, and fibrinogen are usually inherited in an autosomal recessive manner (Table 110- 1). ... coagulation factors have been recognized for centuries. Patients with genetic deficiencies of plasma coagulation factors exhibit lifelong recurrent bleeding episodes into joints, muscles, and closed...
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Chapter 110. Coagulation Disorders (Part 2) potx

Chapter 110. Coagulation Disorders (Part 2) potx

... deficiencies of plasma coagulation are more frequent than congenital disorders; the most common disorders include hemorrhagic diathesis of liver disease, disseminated intravascular coagulation (DIC), ... disease, disseminated intravascular coagulation (DIC), and vitamin K deficiency. In these disorders, blood coagulation is hampered by the deficiency of more than one clotting factor, and the bleeding ... primary (e.g., platelet and vessel wall interactions) and secondary (coagulation) hemostasis. The development of antibodies to coagulation plasma proteins, clinically termed inhibitors, is a relatively...
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Chapter 110. Coagulation Disorders (Part 3) pdf

Chapter 110. Coagulation Disorders (Part 3) pdf

... Chapter 110. Coagulation Disorders (Part 3) Clinically, hemophilia A and hemophilia B are indistinguishable. The ... after major trauma or during routine presurgery laboratory tests. Typically, the global tests of coagulation show only an isolated prolongation of the aPTT assay. Patients with hemophilia have...
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Chapter 110. Coagulation Disorders (Part 4) potx

Chapter 110. Coagulation Disorders (Part 4) potx

... be tapered depending on the extent of the surgical wounds. Oral surgery is Chapter 110. Coagulation Disorders (Part 4) Factor VIII and Factor IX are dosed in units. One unit is by definition...
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Chapter 110. Coagulation Disorders (Part 6) doc

Chapter 110. Coagulation Disorders (Part 6) doc

... Chapter 110. Coagulation Disorders (Part 6) Factor XI Deficiency: Treatment The treatment of FXI deficiency is ... therapy. Other Rare Bleeding Disorders Collectively, the inherited disorders resulting from deficiencies of clotting factors other than FVIII, FIX, and FXI (Table 110- 1) represent a group of ... for plasma coagulation deficiencies are often asymptomatic. The laboratory assessment for the specific deficient factor following screening with general coagulation tests (Table 110- 1) will...
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Chapter 110. Coagulation Disorders (Part 7) pps

Chapter 110. Coagulation Disorders (Part 7) pps

... Recreational drugs (amphetamines) Envenomation Snake Insects Chapter 110. Coagulation Disorders (Part 7) Disseminated Intravascular Coagulation DIC is a clinicopathologic syndrome characterized ... purpura fulminans, with or without thrombosis of large vessels. Table 110- 2 Common Clinical Causes of Disseminated Intravascular Coagulation Sepsis Bacterial Staphylococci, streptococci, ... mechanisms. DIC is associated with several underlying pathologies (Table 110- 2). The most common causes are bacterial sepsis, malignant disorders such as solid tumors or acute promyelocytic leukemia (APL),...
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Chapter 110. Coagulation Disorders (Part 8) ppsx

Chapter 110. Coagulation Disorders (Part 8) ppsx

... Chapter 110. Coagulation Disorders (Part 8) The central mechanism of DIC is the uncontrolled generation of thrombin by exposure of the blood to pathologic levels of tissue factor (Fig. 110- 3). ... mediating the coagulation defects in DIC and symptoms associated with systemic inflammatory response syndrome. Figure 110- 3 The pathophysiology of disseminated intravascular coagulation ... at the time of maximal activation of coagulation. Interestingly, in patients with APL, a severe hyperfibrinolytic state often occurs in addition to the coagulation activation. The release of...
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Chapter 110. Coagulation Disorders (Part 9) ppsx

Chapter 110. Coagulation Disorders (Part 9) ppsx

... membranes (Fig. 110- 2). Inherited deficiency of the functional activity of the enzymes involved in vitamin K metabolism, notably the GGCX or VKOR-1 (see above), results in bleeding disorders. The ... proteases (PCCs), which further aggravates the disease. Replacement of Coagulation or Fibrinolysis Inhibitors Drugs to control coagulation such as heparin, antithrombin III (ATIII) concentrates, ... asymptomatic patients. This strategy can diminish the risk of bleeding while maintaining therapeutic anticoagulation for an underlying prothrombotic state. a dose of 1–2 U/10 kg body weight are sufficient...
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Chapter 110. Coagulation Disorders (Part 11) doc

Chapter 110. Coagulation Disorders (Part 11) doc

... whereas acquired inhibitors are specific to a single factor. Further Readings Chapter 110. Coagulation Disorders (Part 11) Treatment with FFP is the most effective way to correct hemostasis ... patients. Critical Care 10:222, 2006 [PMID: 16879728] Mannucci PM, et al: Recessively inherited coagulation disorders. Blood 104:1243, 2004 [PMID: 15138162] Stafford DW: The vitamin K cycle. J Thromb ... Med 330:39, 1994 Key NS, Negrier C: Coagulation factor concentrates: Past, present, and future. Lancet 370:439, 2007 [PMID: 17679021] Levi M, Opal SM: Coagulation abnormalities in critically...
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