Chapter 109 Disorders of Platelets and Vessel Wall (Part 2) ppsx
Chapter 109. Disorders of Platelets and Vessel Wall (Part 2) ppsx
... macrothrombocytopenia. D. Schistocytes and decreased platelets in microangiopathic hemolytic anemia. Chapter 109. Disorders of Platelets and Vessel Wall (Part 2) Thrombocytopenia Thrombocytopenia ... from one or more of three processes: (1) decreased bone marrow production; (2) sequestration, usually in an enlarged spleen; and/ or (3) increased platelet destruction. Disorders of production ... (green-top tube), or ideally a smear of freshly obtained unanticoagulated blood, such as from a finger stick, can be examined. Figure 109- 1 Photomicrographs of peripheral blood smears....
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Chapter 109. Disorders of Platelets and Vessel Wall (Part 11) ppsx
... course of the illness. Inherited Disorders of the Vessel Wall Patients with inherited disorders of the connective tissue matrix, such as Marfan's syndrome, Ehlers-Danlos syndrome, and pseudoxanthoma ... Willebrand disease. Annu Rev Med 56:173, 2005 [PMID: 15660508] Warkentin TE: Heparin-induced thrombocytopenia. Disease-A-Month 51:141, 2005 [PMID: 15900266] Chapter 109. Disorders of Platelets ... 51:141, 2005 [PMID: 15900266] Chapter 109. Disorders of Platelets and Vessel Wall (Part 11) Metabolic and Inflammatory Disorders Acute febrile illnesses may result in vascular damage. This...
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Chapter 109. Disorders of Platelets and Vessel Wall (Part 1) docx
... enlarges. Platelets are physiologically very Chapter 109. Disorders of Platelets and Vessel Wall (Part 1) Harrison's Internal Medicine > Chapter 109. Disorders of Platelets and Vessel Wall ... Platelets and Vessel Wall Disorders of Platelets and Vessel Wall: Introduction Hemostasis is a dynamic process in which the platelet and the blood vessel wall play key roles. Platelets become activated ... level of TPO, which then stimulates platelet production. Platelets circulate with an average life span of 7–10 days. Approximately one-third of the platelets reside in the spleen, and this...
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Chapter 109. Disorders of Platelets and Vessel Wall (Part 3) pot
... production and platelet Chapter 109. Disorders of Platelets and Vessel Wall (Part 3) Approach to the Patient: Thrombocytopenia The history and physical examination, results of the CBC, and review ... CBC, and review of the peripheral blood smear are all critical components in the initial evaluation of the thrombocytopenic patients (Fig. 109- 2). The overall health of the patient and whether ... thought to denote an increased risk of life-threatening hemorrhage in the thrombocytopenic patient. Excessive bruising is seen in disorders of both platelet number and function. Infection-Induced...
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Chapter 109. Disorders of Platelets and Vessel Wall (Part 4) potx
... thrombocytopenia, timing of platelet count drop, thrombosis and other sequelae such as localized skin reactions, and other cause of thrombocytopenia not evident. Figure 109- 3 ... <20,000/µL. (2) Heparin-induced thrombocytopenia (HIT) is not associated with bleeding and, in fact, markedly increases the risk of thrombosis. HIT results from antibody formation to a complex of the ... have adverse consequences. A fraction of those who develop antibodies will develop thrombocytopenia, and a portion of those (up to 50%) will develop HIT and thrombosis (HITT). HIT can occur...
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Chapter 109. Disorders of Platelets and Vessel Wall (Part 5) ppt
... in treatment of HIT, with prompt discontinuation of heparin and use of alternative anticoagulants. Thrombosis is a common complication of HIT, even after heparin discontinuation, and can occur ... Introduction of warfarin alone in the setting of HIT or HITT may precipitate thrombosis, particularly venous gangrene, presumably due to clotting activation and severely reduced levels of proteins C and ... destruction of platelets and possibly inhibition of platelet release from the megakaryocyte. In children it is usually an acute disease, most commonly following an infection, and with a self-limited...
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Chapter 109. Disorders of Platelets and Vessel Wall (Part 6) potx
... anomaly and Sebastian, Epstein's, and Fechtner syndromes, all of which have distinct distinguishing features. A common feature of these disorders is large Chapter 109. Disorders of Platelets ... Platelets and Vessel Wall (Part 6) Immune Thrombocytopenic Purpura: Treatment The treatment of ITP utilizes drugs that decrease reticuloendothelial uptake of the antibody-bound platelet and/ or ... evident by fragmented RBCs (Fig. 109- 1D) and laboratory evidence of hemolysis, and microvascular thrombosis. This includes thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome...
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Chapter 109. Disorders of Platelets and Vessel Wall (Part 7) ppt
... number of young red blood cells, and nucleated RBCs are often present, which is thought to be due to infarction in the microcirculatory system of the bone marrow. Chapter 109. Disorders of Platelets ... and Vessel Wall (Part 7) Thrombotic Thrombocytopenic Purpura TTP and HUS were previously considered overlap syndromes. However, in the past few years the pathophysiology of inherited and ... clear, and fear of withholding treatment, as well as lack of other treatment alternatives, results in broad application of plasma exchange. However, withdrawal, or reduction in dose, of endothelial...
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Chapter 109. Disorders of Platelets and Vessel Wall (Part 8) potx
... Disorders of Platelet Function Inherited Disorders of Platelet Function Inherited platelet function disorders are thought to be relatively rare, although the prevalence of mild disorders of ... for such disorders is suboptimal. Rare qualitative disorders include the autosomal recessive disorders Glanzmann's thrombasthenia (absence of the platelet GpIIbIIIa receptor) and Bernard ... abnormalities of platelet granule formation. It is also seen as a part of inherited disorders of granule formation, such as Hermansky-Pudlak syndrome. Bleeding symptoms in SPD are variable but often...
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Chapter 109. Disorders of Platelets and Vessel Wall (Part 9) pdf
... 1 Nl or up down down down Normal distribution, Chapter 109. Disorders of Platelets and Vessel Wall (Part 9) von Willebrand Disease vWD is the most common inherited bleeding disorder. ... subtypes of type 2 (Table 109- 2). By far the most common type of vWD is type 1 disease, with a parallel decrease in vWF protein, vWF function, and FVIII levels, accounting for at least 80% of cases. ... platelet disorders. Frequently, mild type 1 vWD first manifests with dental extractions, particularly wisdom tooth extraction, or tonsillectomy. Table 109- 2 Laboratory Diagnosis of von Willebrand...
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