Chapter 109 Disorders of Platelets and Vessel Wall (Part 2) ppsx

... macrothrombocytopenia. D. Schistocytes and decreased platelets in microangiopathic hemolytic anemia. Chapter 109. Disorders of Platelets and Vessel Wall (Part 2) Thrombocytopenia Thrombocytopenia ... from one or more of three processes: (1) decreased bone marrow production; (2) sequestration, usually in an enlarged spleen; and/ or (3) increased platel...

Ngày tải lên: 07/07/2014, 04:20

... course of the illness. Inherited Disorders of the Vessel Wall Patients with inherited disorders of the connective tissue matrix, such as Marfan's syndrome, Ehlers-Danlos syndrome, and pseudoxanthoma ... Willebrand disease. Annu Rev Med 56:173, 2005 [PMID: 15660508] Warkentin TE: Heparin-induced thrombocytopenia. Disease-A- Month 51:141, 2005 [PMID: 15900266] Ch...

Ngày tải lên: 07/07/2014, 04:20

... enlarges. Platelets are physiologically very Chapter 109. Disorders of Platelets and Vessel Wall (Part 1) Harrison's Internal Medicine > Chapter 109. Disorders of Platelets and Vessel Wall ... Platelets and Vessel Wall Disorders of Platelets and Vessel Wall: Introduction Hemostasis is a dynamic process in which the platelet a...

Ngày tải lên: 07/07/2014, 04:20

... production and platelet Chapter 109. Disorders of Platelets and Vessel Wall (Part 3) Approach to the Patient: Thrombocytopenia The history and physical examination, results of the CBC, and review ... CBC, and review of the peripheral blood smear are all critical components in the initial evaluation of the thrombocytopenic patients (Fig. 109- 2). The ov...

Ngày tải lên: 07/07/2014, 04:20

... thrombocytopenia, timing of platelet count drop, thrombosis and other sequelae such as localized skin reactions, and other cause of thrombocytopenia not evident. Figure 109- 3 ... <20,000/µL. (2) Heparin-induced thrombocytopenia (HIT) is not associated with bleeding and, in fact, markedly increases the risk of thrombosis. HIT results from antibody formation to a com...

Ngày tải lên: 07/07/2014, 04:20

... in treatment of HIT, with prompt discontinuation of heparin and use of alternative anticoagulants. Thrombosis is a common complication of HIT, even after heparin discontinuation, and can occur ... Introduction of warfarin alone in the setting of HIT or HITT may precipitate thrombosis, particularly venous gangrene, presumably due to clotting activation and severely reduced...

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... anomaly and Sebastian, Epstein's, and Fechtner syndromes, all of which have distinct distinguishing features. A common feature of these disorders is large Chapter 109. Disorders of Platelets ... Platelets and Vessel Wall (Part 6) Immune Thrombocytopenic Purpura: Treatment The treatment of ITP utilizes drugs that decrease reticuloendothelial uptake o...

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... number of young red blood cells, and nucleated RBCs are often present, which is thought to be due to infarction in the microcirculatory system of the bone marrow. Chapter 109. Disorders of Platelets ... and Vessel Wall (Part 7) Thrombotic Thrombocytopenic Purpura TTP and HUS were previously considered overlap syndromes. However, in the past few years the path...

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... Disorders of Platelet Function Inherited Disorders of Platelet Function Inherited platelet function disorders are thought to be relatively rare, although the prevalence of mild disorders of ... for such disorders is suboptimal. Rare qualitative disorders include the autosomal recessive disorders Glanzmann's thrombasthenia (absence of the platelet GpIIbIIIa rec...

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... 1 Nl or up down down down Normal distribution, Chapter 109. Disorders of Platelets and Vessel Wall (Part 9) von Willebrand Disease vWD is the most common inherited bleeding disorder. ... subtypes of type 2 (Table 109- 2). By far the most common type of vWD is type 1 disease, with a parallel decrease in vWF protein, vWF function, and FVIII levels, ac...

Ngày tải lên: 07/07/2014, 04:20