Chapter 108 Hematopoietic Cell Transplantation (Part 7) potx
Chapter 108. Hematopoietic Cell Transplantation (Part 7) potx
... Using Hematopoietic Cell
Transplantation
Nonmalignant Diseases: Treatment
Immunodeficiency Disorders
By replacing abnormal stem cells with cells from a normal donor,
hematopoietic cell transplantation ...
Hodgkin's disease
First
relapse/second
remission
40 50
Chapter 108. Hematopoietic
Cell Transplantation
(Part 7)
Pneumocystis jiroveci pneumonia, o...
Chapter 108. Hematopoietic Cell Transplantation (Part 4) potx
... syndromes complicating marrow transplantation.
VOD, venoocclusive disease; GVHD, graft-versus-
host disease; HSV,
herpes simplex virus; CMV, cytomegalovirus; VZV, varicella-
zoster virus. The
size ... their hair 5–6 days
posttransplant and by 1 week are usually profoundly pancytopenic.
Figure 108- 1
Although most pneumonias developing posttransplant are caused by
infectious...
Chapter 108. Hematopoietic Cell Transplantation (Part 5) potx
... second general approach to GVHD prevention is removal of T
cells from the stem cell inoculum. While effective in preventing GVHD, T cell
depletion is associated with an increased incidence of ...
receiving stem cells from unrelated donors. The disease is usually treated with
glucocorticoids, antithymocyte globulin, or monoclonal antibodies targeted against
T cells or T cell subsets...
Chapter 108. Hematopoietic Cell Transplantation (Part 1) pps
... siblings.
Chapter 108. Hematopoietic
Cell Transplantation
(Part 1)
Harrison's Internal Medicine > Chapter 108. Hematopoietic Cell
Transplantation
Hematopoietic Cell Transplantation: ... of the patient with high-dose myelotoxic therapy.
Categories of Hematopoietic Cell Transplantation
Hematopoietic cell transplantation can be described acc...
Chapter 108. Hematopoietic Cell Transplantation (Part 2) ppt
... been the source of hematopoietic stem cells for transplantation.
Typically, anywhere from 1.5 to 5 x 10
8
nucleated marrow cells per kilogram are
collected for allogeneic transplantation. Several ... stem cells resulting in improved overall survival.
Umbilical cord blood contains a high concentration of hematopoietic
progenitor cells, allowing for its use as a source of stem cells...
Chapter 108. Hematopoietic Cell Transplantation (Part 3) pptx
... a similar
Chapter 108. Hematopoietic
Cell Transplantation
(Part 3)
The Transplant Preparative Regimen
The treatment regimen administered to patients immediately preceding
transplantation ... of red cells to prevent hemolysis in ABO-incompatible transplants,
the removal of donor T cells to prevent GVHD, or attempts to remove possible
contaminating tumor cells in autologous...
Chapter 108. Hematopoietic Cell Transplantation (Part 6) pps
...
common following use of less-immunosuppressive preparative regimens, in
recipients of T cell depleted stem cell products, and in patients receiving grafts
from HLA-mismatched donors.
Treatment ...
Posttransplant patients, particularly recipients of allogeneic transplantation,
require unique approaches to the problem of infection. Early after transplantation,
patients are profoundl...
Chapter 108. Hematopoietic Cell Transplantation (Part 8) doc
... malignancies have been cured of both with transplantation.
Malignant Diseases: Treatment
Chapter 108. Hematopoietic
Cell Transplantation
(Part 8)
Aplastic Anemia
Transplantation from matched siblings ... compared to allogeneic transplantation. On balance, most experts
recommend use of allogeneic stem cells if an appropriate donor is available.
Theoretically, hematopo...
Chapter 108. Hematopoietic Cell Transplantation (Part 9) ppt
... Readings
Appelbaum FR: Haematopoietic cell transplantation as immunotherapy.
Nature 411:385, 2001 [PMID: 11357147]
Baron F, Storb R: Hematopoietic stem cell transplantation after reduced-
i
ntensity ... stem-
cell transplantation. N Engl J Med
354:1813, 2006 [PMID: 16641398]
Petersdorf EW et al: Major-histocompatibility-
complex class I alleles and
antigens in hematopoieti...
Chapter 106. Plasma Cell Disorders (Part 7) potx
... Chapter 106. Plasma Cell Disorders
(Part 7)
Serum β
2
-microglobulin is a protein of 11,000 mol wt with homologies ... reliable measure of tumor cell
kill. Calculations of tumor cell kill are made by extrapolation of the serum M
component level and rely heavily on the assumption that every tumor cell
produces immunoglobulin ... hyperploidy, chromosome 13q and 17p deletio...
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