Chapter 108 Hematopoietic Cell Transplantation (Part 7) potx

... Using Hematopoietic Cell Transplantation Nonmalignant Diseases: Treatment Immunodeficiency Disorders By replacing abnormal stem cells with cells from a normal donor, hematopoietic cell transplantation ... Hodgkin's disease First relapse/second remission 40 50 Chapter 108. Hematopoietic Cell Transplantation (Part 7) Pneumocystis jiroveci pneumonia, o...

Ngày tải lên: 07/07/2014, 04:20

... syndromes complicating marrow transplantation. VOD, venoocclusive disease; GVHD, graft-versus- host disease; HSV, herpes simplex virus; CMV, cytomegalovirus; VZV, varicella- zoster virus. The size ... their hair 5–6 days posttransplant and by 1 week are usually profoundly pancytopenic. Figure 108- 1 Although most pneumonias developing posttransplant are caused by infectious...

Ngày tải lên: 07/07/2014, 04:20

... second general approach to GVHD prevention is removal of T cells from the stem cell inoculum. While effective in preventing GVHD, T cell depletion is associated with an increased incidence of ... receiving stem cells from unrelated donors. The disease is usually treated with glucocorticoids, antithymocyte globulin, or monoclonal antibodies targeted against T cells or T cell subsets...

Ngày tải lên: 07/07/2014, 04:20

... siblings. Chapter 108. Hematopoietic Cell Transplantation (Part 1) Harrison's Internal Medicine > Chapter 108. Hematopoietic Cell Transplantation Hematopoietic Cell Transplantation: ... of the patient with high-dose myelotoxic therapy. Categories of Hematopoietic Cell Transplantation Hematopoietic cell transplantation can be described acc...

Ngày tải lên: 07/07/2014, 04:20

... been the source of hematopoietic stem cells for transplantation. Typically, anywhere from 1.5 to 5 x 10 8 nucleated marrow cells per kilogram are collected for allogeneic transplantation. Several ... stem cells resulting in improved overall survival. Umbilical cord blood contains a high concentration of hematopoietic progenitor cells, allowing for its use as a source of stem cells...

Ngày tải lên: 07/07/2014, 04:20

... a similar Chapter 108. Hematopoietic Cell Transplantation (Part 3) The Transplant Preparative Regimen The treatment regimen administered to patients immediately preceding transplantation ... of red cells to prevent hemolysis in ABO-incompatible transplants, the removal of donor T cells to prevent GVHD, or attempts to remove possible contaminating tumor cells in autologous...

Ngày tải lên: 07/07/2014, 04:20

... common following use of less-immunosuppressive preparative regimens, in recipients of T cell depleted stem cell products, and in patients receiving grafts from HLA-mismatched donors. Treatment ... Posttransplant patients, particularly recipients of allogeneic transplantation, require unique approaches to the problem of infection. Early after transplantation, patients are profoundl...

Ngày tải lên: 07/07/2014, 04:20

... malignancies have been cured of both with transplantation. Malignant Diseases: Treatment Chapter 108. Hematopoietic Cell Transplantation (Part 8) Aplastic Anemia Transplantation from matched siblings ... compared to allogeneic transplantation. On balance, most experts recommend use of allogeneic stem cells if an appropriate donor is available. Theoretically, hematopo...

Ngày tải lên: 07/07/2014, 04:20

... Readings Appelbaum FR: Haematopoietic cell transplantation as immunotherapy. Nature 411:385, 2001 [PMID: 11357147] Baron F, Storb R: Hematopoietic stem cell transplantation after reduced- i ntensity ... stem- cell transplantation. N Engl J Med 354:1813, 2006 [PMID: 16641398] Petersdorf EW et al: Major-histocompatibility- complex class I alleles and antigens in hematopoieti...

Ngày tải lên: 07/07/2014, 04:20

... Chapter 106. Plasma Cell Disorders (Part 7) Serum β 2 -microglobulin is a protein of 11,000 mol wt with homologies ... reliable measure of tumor cell kill. Calculations of tumor cell kill are made by extrapolation of the serum M component level and rely heavily on the assumption that every tumor cell produces immunoglobulin ... hyperploidy, chromosome 13q and 17p deletio...

Ngày tải lên: 07/07/2014, 04:20