Chapter 108 Hematopoietic Cell Transplantation (Part 5) potx

... second general approach to GVHD prevention is removal of T cells from the stem cell inoculum. While effective in preventing GVHD, T cell depletion is associated with an increased incidence of ... receiving stem cells from unrelated donors. The disease is usually treated with glucocorticoids, antithymocyte globulin, or monoclonal antibodies targeted against T cells or T cell subsets...

Ngày tải lên: 07/07/2014, 04:20

... syndromes complicating marrow transplantation. VOD, venoocclusive disease; GVHD, graft-versus- host disease; HSV, herpes simplex virus; CMV, cytomegalovirus; VZV, varicella- zoster virus. The size ... their hair 5–6 days posttransplant and by 1 week are usually profoundly pancytopenic. Figure 108- 1 Although most pneumonias developing posttransplant are caused by infectious...

Ngày tải lên: 07/07/2014, 04:20

... Using Hematopoietic Cell Transplantation Nonmalignant Diseases: Treatment Immunodeficiency Disorders By replacing abnormal stem cells with cells from a normal donor, hematopoietic cell transplantation ... 40 Hodgkin's disease First relapse/second remission 40 50 Chapter 108. Hematopoietic Cell Transplantation (Part 7) Pneumocystis jiroveci pneumonia,...

Ngày tải lên: 07/07/2014, 04:20

... (0. 75) n , where n equals the number of siblings. Chapter 108. Hematopoietic Cell Transplantation (Part 1) Harrison's Internal Medicine > Chapter 108. Hematopoietic Cell Transplantation ... Transplantation Hematopoietic Cell Transplantation: Introduction Bone marrow transplantation was the original term used to describe the collection and transp...

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... been the source of hematopoietic stem cells for transplantation. Typically, anywhere from 1.5 to 5 x 10 8 nucleated marrow cells per kilogram are collected for allogeneic transplantation. Several ... stem cells resulting in improved overall survival. Umbilical cord blood contains a high concentration of hematopoietic progenitor cells, allowing for its use as a source of stem cells...

Ngày tải lên: 07/07/2014, 04:20

... a similar Chapter 108. Hematopoietic Cell Transplantation (Part 3) The Transplant Preparative Regimen The treatment regimen administered to patients immediately preceding transplantation ... of red cells to prevent hemolysis in ABO-incompatible transplants, the removal of donor T cells to prevent GVHD, or attempts to remove possible contaminating tumor cells in autologous...

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... common following use of less-immunosuppressive preparative regimens, in recipients of T cell depleted stem cell products, and in patients receiving grafts from HLA-mismatched donors. Treatment ... Posttransplant patients, particularly recipients of allogeneic transplantation, require unique approaches to the problem of infection. Early after transplantation, patients are profoundl...

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... malignancies have been cured of both with transplantation. Malignant Diseases: Treatment Chapter 108. Hematopoietic Cell Transplantation (Part 8) Aplastic Anemia Transplantation from matched siblings ... compared to allogeneic transplantation. On balance, most experts recommend use of allogeneic stem cells if an appropriate donor is available. Theoretically, hematopo...

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... Readings Appelbaum FR: Haematopoietic cell transplantation as immunotherapy. Nature 411:385, 2001 [PMID: 11357147] Baron F, Storb R: Hematopoietic stem cell transplantation after reduced- i ntensity ... stem- cell transplantation. N Engl J Med 354:1813, 2006 [PMID: 16641398] Petersdorf EW et al: Major-histocompatibility- complex class I alleles and antigens in hematopoieti...

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... Else Can Hematopoietic Stem Cells Do? Some experimental data have suggested that hematopoietic stem cells or other cells mobilized into the circulation by the same factors that mobilize hematopoietic ... experimentally in the hematopoietic system. Taking advantage of the cell- surface markers that distinguish hematopoietic cells of varying maturity, stem cells, progenitors, pr...

Ngày tải lên: 07/07/2014, 01:20