Chapter 106 Plasma Cell Disorders (Part 7) potx
Chapter 106. Plasma Cell Disorders (Part 7) potx
... Chapter 106. Plasma Cell Disorders
(Part 7)
Serum β
2
-microglobulin is a protein of 11,000 mol wt with homologies ... including hyperploidy, chromosome 13q and 17p deletion, t(4;14)
and t(11;14); % plasma cells in the marrow; circulating plasma cells; performance
status; as well as serum levels of soluble IL-6 receptor, ... reliable measure of tumor cell
kill. Calc...
Chapter 106. Plasma Cell Disorders (Part 2) potx
... apparatus. Binucleate and multinucleate
malignant plasma cells can be seen.
Chapter 106. Plasma Cell Disorders
(Part 2)
Figure 106- 1
Representative patterns of serum electrophoresis.
... petroleum products. The
neoplastic event in myeloma may involve cells earlier in B cell differentiation than
the plasma cell. Circulating B cells bearing surface immuno...
Chapter 106. Plasma Cell Disorders (Part 8) potx
... to the tumor.
Chapter 106. Plasma Cell Disorders
(Part 8)
Randomized studies comparing standard-dose therapy to high-dose
melphalan therapy (HDT) with hematopoietic stem cell support have ... agents including lenalidomide
and/or bortezomib. These agents target not only the tumor cell but also the tumor
cell bone marrow interaction and the bone marrow milieu. These age...
Chapter 106. Plasma Cell Disorders (Part 9) potx
... patients and have been associated with prolonged progression-
free survival.
Chapter 106. Plasma Cell Disorders
(Part 9)
The cause of macroglobulinemia is unknown. The disease is similar ... hyperviscosity symptoms such as an altered state of
consciousness or paresis can be achieved acutely by plasmapheresis because 80%
of the IgM paraprotein is intravascular. The median s...
Chapter 106. Plasma Cell Disorders (Part 1) ppsx
...
(Part 1)
Harrison's Internal Medicine > Chapter 106. Plasma Cell Disorders
Plasma Cell Disorders: Introduction
The plasma cell disorders are monoclonal neoplasms related to each other ... antibody-producing cells. Idiotypes are formed by
the unique structure of the antigen-binding portion of the molecule.
Chapter 106. Plasma Cell Disorders
(Part...
Chapter 106. Plasma Cell Disorders (Part 3) ppsx
... resistance. HSP, heparin sulfate
proteoglycan.
Table 106- 1 Clinical Features of Multiple Myeloma
Chapter 106. Plasma Cell Disorders
(Part 3)
Incidence and Prevalence
About 19,900 cases ...
Figure 106- 3
Pathogenesis of multiple myeloma.
Multiple myeloma cells interact with
bone marrow stromal
cells and extracellular matrix proteins via adhesion
molecules,...
Chapter 106. Plasma Cell Disorders (Part 4) ppt
... Chapter 106. Plasma Cell Disorders
(Part 4)
Bone pain is the most common symptom in myeloma, affecting nearly ... polysaccharide antigens
such as those on bacterial cell walls. Most measures of T cell function in myeloma
are normal, but a subset of CD4+ cells may be decreased. Granulocyte lysozyme
is plain ... tumor cells, activation of osteoclasts that destroy bone, an...
Chapter 106. Plasma Cell Disorders (Part 5) pot
... spleen, lymph nodes, or gut-
associated lymphatic tissue.
Diagnosis and Staging
Chapter 106. Plasma Cell Disorders
(Part 5)
Anemia occurs in ~80% of myeloma patients. It is usually normocytic ... significance (MGUS)
M protein in serum < 30 g/L
Bone marrow clonal plasma cells < 10%
No evidence of other B cell proliferative disorders
No myeloma-
related orga...
Chapter 106. Plasma Cell Disorders (Part 10) doc
...
Oncol 25:2464, 2007
Mitsiades CS et al: Focus on multiple myeloma. Cancer Cell 6:439, 2005
Munshi NC, Anderson KC: Plasma cell neoplasm, in
Principles and
Practice of Oncology
, 7th ed, V DeVita, ... characterized by an
infiltration of the lamina propria of the small intestine with lymphoplasmacytoid
cells that secrete truncated alpha chains. Demonstrating alpha heavy chains is...
Chapter 108. Hematopoietic Cell Transplantation (Part 7) potx
... Hematopoietic Cell
Transplantation
Nonmalignant Diseases: Treatment
Immunodeficiency Disorders
By replacing abnormal stem cells with cells from a normal donor,
hematopoietic cell transplantation ...
Hodgkin's disease
First
relapse/second
remission
40 50
Chapter 108. Hematopoietic
Cell Transplantation
(Part 7)
Pneumocystis jiroveci pneumonia, once seen in 5–1...
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