Chapter 106 Plasma Cell Disorders (Part 4) ppt

... Chapter 106. Plasma Cell Disorders (Part 4) Bone pain is the most common symptom in myeloma, affecting nearly 70% ... polysaccharide antigens such as those on bacterial cell walls. Most measures of T cell function in myeloma are normal, but a subset of CD4+ cells may be decreased. Granulocyte lysozyme is plain ... be palpated, especially on the skull (Fig. 106- 4),...

Ngày tải lên: 07/07/2014, 04:20

... (Part 1) Harrison's Internal Medicine > Chapter 106. Plasma Cell Disorders Plasma Cell Disorders: Introduction The plasma cell disorders are monoclonal neoplasms related to each other ... antibody-producing cells. Idiotypes are formed by the unique structure of the antigen-binding portion of the molecule. Chapter 106. Plasma Cell Disorders (Part...

Ngày tải lên: 07/07/2014, 04:20

... apparatus. Binucleate and multinucleate malignant plasma cells can be seen. Chapter 106. Plasma Cell Disorders (Part 2) Figure 106- 1 Representative patterns of serum electrophoresis. ... petroleum products. The neoplastic event in myeloma may involve cells earlier in B cell differentiation than the plasma cell. Circulating B cells bearing surface immuno...

Ngày tải lên: 07/07/2014, 04:20

... resistance. HSP, heparin sulfate proteoglycan. Table 106- 1 Clinical Features of Multiple Myeloma Chapter 106. Plasma Cell Disorders (Part 3) Incidence and Prevalence About 19,900 cases ... Figure 106- 3 Pathogenesis of multiple myeloma. Multiple myeloma cells interact with bone marrow stromal cells and extracellular matrix proteins via adhesion molecules,...

Ngày tải lên: 07/07/2014, 04:20

... spleen, lymph nodes, or gut- associated lymphatic tissue. Diagnosis and Staging Chapter 106. Plasma Cell Disorders (Part 5) Anemia occurs in ~80% of myeloma patients. It is usually normocytic ... significance (MGUS) M protein in serum < 30 g/L Bone marrow clonal plasma cells < 10% No evidence of other B cell proliferative disorders No myeloma- related orga...

Ngày tải lên: 07/07/2014, 04:20

... Chapter 106. Plasma Cell Disorders (Part 7) Serum β 2 -microglobulin is a protein of 11,000 mol wt with homologies ... abnormalities including hyperploidy, chromosome 13q and 17p deletion, t(4; 14) and t(11; 14); % plasma cells in the marrow; circulating plasma cells; performance status; as well as serum levels of soluble ... reliable measure of tumor cell kill. Cal...

Ngày tải lên: 07/07/2014, 04:20

... to the tumor. Chapter 106. Plasma Cell Disorders (Part 8) Randomized studies comparing standard-dose therapy to high-dose melphalan therapy (HDT) with hematopoietic stem cell support have ... agents including lenalidomide and/or bortezomib. These agents target not only the tumor cell but also the tumor cell bone marrow interaction and the bone marrow milieu. These age...

Ngày tải lên: 07/07/2014, 04:20

... patients and have been associated with prolonged progression- free survival. Chapter 106. Plasma Cell Disorders (Part 9) The cause of macroglobulinemia is unknown. The disease is similar ... hyperviscosity symptoms such as an altered state of consciousness or paresis can be achieved acutely by plasmapheresis because 80% of the IgM paraprotein is intravascular. The median s...

Ngày tải lên: 07/07/2014, 04:20

... Oncol 25:2464, 2007 Mitsiades CS et al: Focus on multiple myeloma. Cancer Cell 6:439, 2005 Munshi NC, Anderson KC: Plasma cell neoplasm, in Principles and Practice of Oncology , 7th ed, V DeVita, ... characterized by an infiltration of the lamina propria of the small intestine with lymphoplasmacytoid cells that secrete truncated alpha chains. Demonstrating alpha heavy chains is...

Ngày tải lên: 07/07/2014, 04:20

... and increase the risk for falls. These disorders are important to recognize because they are often treatable. Psychogenic Gait Disorder Psychogenic disorders are common in outpatient practice, ... substantial burden of white matter disease will ultimately impact cerebral control of locomotion. Disorders of Balance Balance is the ability to maintain equilibrium: a state in which opp...

Ngày tải lên: 06/07/2014, 13:20