Chapter 105 Malignancies of Lymphoid Cells (Part 10) potx

... lymphoma stratified according to the IPI. Chapter 105. Malignancies of Lymphoid Cells (Part 10) Table 105- 9 International Prognostic Index for NHL Five clinical risk factors: ... Relationship of International Prognostic Index (IPI) to survival. Kaplan- Meier survival curves for 1300 patients with various kinds of lymphoma stratified according to the IP...

Ngày tải lên: 07/07/2014, 04:20

... prognostic significance and should not be used to assign a higher stage. Table 105- 7 Staging of Typical B Cell Lymphoid Leukemia Stage Clinical Features Median Survival, Years establish ... hypogammaglobulinemia benefit from regular (monthly) γ globulin administration. Because of expense, γ globulin is often withheld until the patient experiences a significant infection. Thes...

Ngày tải lên: 07/07/2014, 04:20

... lymphoma Chapter 105. Malignancies of Lymphoid Cells (Part 1) Harrison's Internal Medicine > Chapter 105. Malignancies of Lymphoid Cells Malignancies of Lymphoid Cells: Introduction ... Introduction Malignancies of lymphoid cells range from the most indolent to the most aggressive human malignancies. These cancers arise from cells...

Ngày tải lên: 07/07/2014, 04:20

... lymphoid tissue; NK, natural killer; WHO, World Health Organization. Malignancies in bold occur in at least 1% of patients. Source: Adapted from Harris et al. Chapter 105. Malignancies of ... Chapter 105. Malignancies of Lymphoid Cells (Part 2) Non-Hodgkin's lymphomas were separated from Hodgkin's disease by recognition of the Sternberg-Reed cel...

Ngày tải lên: 07/07/2014, 04:20

... Chapter 105. Malignancies of Lymphoid Cells (Part 3) General Aspects of Lymphoid Malignancies Etiology and Epidemiology The relative frequency of the various lymphoid malignancies ... frequency of the various lymphoid malignancies is shown in Fig. 105- 1. Chronic lymphoid leukemia (CLL) is the most prevalent form of leukemia in western countries. I...

Ngày tải lên: 07/07/2014, 04:20

... Chapter 105. Malignancies of Lymphoid Cells (Part 4) The incidence of non-Hodgkin's lymphomas and the patterns of expression of the various subtypes differ ... transfusion-transmitted virus (Chap. 181). Table 105- 4 Infectious Agents Associated with the Development of Lymphoid Malignancies Infectious Agent Lymphoid Malignancy Note: CNS, centra l ner...

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... Chapter 105. Malignancies of Lymphoid Cells (Part 5) Table 105- 5 Diseases or Exposures Associated with Increased Risk of Development of Malignant Lymphoma Inherited ... activation of a series of transcription factors, the cell first becomes committed to the lymphoid lineage and then gives rise to B and T cells. About 75% of all lymphoid leukemias and 90...

Ngày tải lên: 07/07/2014, 04:20

... Chapter 105. Malignancies of Lymphoid Cells (Part 6) Figure 105- 3 In the case of diffuse large B cell lymphoma, the translocation t(14;18) occurs in ~30% of patients and ... stimulus. Malignancies of lymphoid cells are associated with recurring genetic abnormalities. While specific genetic abnormalities have not been identified for all subtypes of lympho...

Ngày tải lên: 07/07/2014, 04:20

... frame. Chapter 105. Malignancies of Lymphoid Cells (Part 7) Table 105- 6 presents the best documented translocations and associated oncogenes for various subtypes of lymphoid malignancies. ... the identification of patterns of gene expression with diagnostic and/or prognostic significance, and the identification of new therapeutic targets. Recognition of pa...

Ngày tải lên: 07/07/2014, 04:20

... Chapter 105. Malignancies of Lymphoid Cells (Part 9) Two other features may be used to assess prognosis in B cell ... classification. At least two subsets of CLL have been identified based on the cytoplasmic expression of ZAP-70; expression of this protein, which is usually expressed in T cells, identifies a subgroup ... Hodgkin's disease (Table 105- 8). Tabl...

Ngày tải lên: 07/07/2014, 04:20