Chapter 101 Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 15) potx

... to Waldenström macroglobulinemia (WM; Chap. 106), although in most cases the other clinical hours is probably unique to this condition. Chapter 101. Hemolytic Anemias and Anemia Due to ... unique to this condition. Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 15) Severe acute AIHA can be a medical emerge...

Ngày tải lên: 07/07/2014, 04:20

... intervals also ameliorated the anemia in most patients and dramatically improved their quality of life. Figure 101- 9 Therapeutic efficacy of an anti-C5 antibody on the anemia of paroxysmal ... globulin (ALG or ATG) and cyclosporine A may be indicated. Although no formal trial has ever been conducted, this approach has helped particularly to relieve severe thrombocytop...

Ngày tải lên: 07/07/2014, 04:20

... Extracorpuscular Factors Hereditary Hemoglobinopathies Familial hemolytic uremic syndrome (HUS) Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 1) Harrison's ... of anemia in these two groups of patients are quite different, and they will be considered separately. Hemolytic Anemias Anemias due to increased destr...

Ngày tải lên: 07/07/2014, 04:20

... often associated with hemosiderinuria and an Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 2) Table 101- 2 General Features of Hemolytic Disorders General examination ... pyknosis and actual loss of the nucleus. Reticulocytes Increased Bilirubin Increased (mostly unconjugated) LDH Increased (up to 10X normal with...

Ngày tải lên: 07/07/2014, 04:20

... Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 3) Figure 101- 1 cause considerable iron loss, needing replacement. With chronic ... needs frequent blood transfusions. Chronic iron overload will cause secondary hemochromatosis; this will cause damage, particularly to the liver, eventually leading to cirrhosis, and to the heart...

Ngày tải lên: 07/07/2014, 04:20

... instead autosomal recessive (with the patient being homozygous). Figure 101- 3 Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 5) Hemolytic Anemias Due to Abnormalities ... (including ankyrin and the so-called band 4.1 and band 4.2), which thus connect these two structures intimately. Figure 101- 2 Diagram of red ce...

Ngày tải lên: 07/07/2014, 04:20

... Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 6) Peripheral blood smear from patients with membrane-cytoskeleton abnormalities. A. Hereditary spherocytosis. ... Hereditary elliptocytosis, heterozygote. C. Elliptocytosis, with both alleles of the α-spectrin gene mutated. [From L Luzzatto, in J Gribben and D Pravan (eds): Molecular H...

Ngày tải lên: 07/07/2014, 04:20

... Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 7) Clinical Presentation and Diagnosis The spectrum of clinical severity ... prophylaxis postsplenectomy is controversial. 4. HS patients often may require cholecystectomy. It used to be considered mandatory to combine this procedure with splenectomy, but this may not ... HE causing...

Ngày tải lên: 07/07/2014, 04:20

... Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 8) Abnormalities of the Glycolytic Pathway (Fig. 101- 1) Since red cells, in the course ... the jaundice persists and is usually associated with a very high reticulocytosis. The anemia is of variable severity; sometimes it is so severe as to require regular blood transfusions; somet...

Ngày tải lên: 07/07/2014, 04:20

... directly and via reduced glutathione (GSH), defends these cells against oxidative stress. G6PD deficiency is a prime example of an HA due to interaction between an intracorpuscular and an extracorpuscular ... G6PD activity in most tissues, this is less marked than in red cells, and it does not seem to produce symptoms. Figure 101- 4 Diagram of redox metabolism in the r...

Ngày tải lên: 07/07/2014, 04:20