... replication in most organs, including the liver,spleen, and eventually the brain [284]. The disseminationof infection to the brain and the severity of infection of the peripheral organs depend in part ... The macro-phages are thus a blind end for the HSV infection, and they can in that way protect other cells from infection, forexample as a barrier lining the liver sinusoids [344]. The extrinsic ... cycle of the virus. A little later, other cytokines such as IL-12, IL-18 and IFN-γ are produced and give rise to other weapons in the battle against the virus. They will, in turn, within the nextreplication...