... Chapter 091. Benign and Malignant Diseases of the Prostate (Part 8) For patients with a rising PSA after radiation therapy, salvage prostatectomy can be considered if the disease ... hormone and follicle-stimulating hormone followed by a downregulation of receptors in the pituitary gland, which effects a chemical castration. They were approved on the basis of randomized ... included the Gleason grade of the primary tumor, time to recurrence, and PSA doubling times. For those with Gleason grade ≥8 tumors, the probability of metastatic progression was 37, 51, and 71%...