... cancers other than lung cancer, nor in lung cancers that have KRAS mutations. These EGFR mutations, often associated with amplification of the EGFR gene, usually confer sensitivity of these lung ... Chapter 085. Neoplasms of the Lung (Part 4) Inherited Predisposition to Lung Cancer While an inherited predisposition to develop lung cancer is not common, several ... cases the development of EGFR TKI resistance is associated with the development of another mutation in the EGFR gene (T790M mutation), or amplification of the c-met oncogene. However, other...