Chapter 080 Cancer Cell Biology and Angiogenesis (Part 18) doc
Chapter 080. Cancer Cell Biology and Angiogenesis (Part 18) doc
... Chapter 080. Cancer Cell Biology
and Angiogenesis
(Part 18)
Antiangiogenic Therapy
Understanding the molecular mechanisms that regulate tumor angiogenesis
may provide ... with advanced colon, lung, and breast cancers, and in the
second-line treatment of colon cancer. However, not all trials have been positive;
in previously treated breast cancer, the addition...
Chapter 080. Cancer Cell Biology and Angiogenesis (Part 7) docx
... the cancer cell, without
harming normal cells (which maintain wild-type function for gene A). High-
throughput screens can now be performed
using isogenic cell line pairs in which
one cell ... transition and passage through the cell cycle. Inhibition of one pathway
(such as pathway A by a targeted inhibitor) has no significant effect due to
redundancy provi
ded by pathways B...
Chapter 080. Cancer Cell Biology and Angiogenesis (Part 10) docx
... the onl
y target for proteasome
inhibitors.
Chapter 080. Cancer Cell Biology
and Angiogenesis
(Part 10)
Estrogen receptors (ERs) and androgen receptors, members of the steroid
hormone ... used to
treat breast and prostate cancers, respectively. Tamoxifen, a partial agonist and
antagonist of ER function, can mediate tumor regression in metastatic breast
cance...
Chapter 080. Cancer Cell Biology and Angiogenesis (Part 14) doc
... as VEGF and
angiopoietins (see below), tumor vessels are tortuous and dilated with an uneven
Chapter 080. Cancer Cell Biology
and Angiogenesis
(Part 14)
Oncogene Addiction and Synthetic ... addiction and synthetic lethality have spurred
new drug development targeting oncogene and tumor-suppressor pathways. As
discussed earlier in this chapter and outli...
Chapter 080. Cancer Cell Biology and Angiogenesis (Part 15) doc
...
Chapter 080. Cancer Cell Biology
and Angiogenesis
(Part 15)
Tumor angiogenesis is a complex process involving many different cell
types that must proliferate, migrate, invade, and differentiate ... tortuous, dilated, leaky, and
extracellular matrix and mediate endothelial cells adhesion, migration, and
invasion. Endothelial cells (ECs) also express RTK (i....
Chapter 080. Cancer Cell Biology and Angiogenesis (Part 1) pps
... synthesis and mitosis and in response to environmental
mutagens; these repair pathways are often abnormal in cancer cells. When a
normal cell has sustained too much damage to repair, the cell activates ... damage to the organ. These cell death pathways are also
commonly altered in cancer cells, leading to the survival of damaged cells that
would normally die. Cancer cells...
Chapter 080. Cancer Cell Biology and Angiogenesis (Part 2) ppsx
...
whether a cell will enter S-phase. The complex of CDK4 or CDK6 with D type
cyclins forms a G
1
-specific kinase whose activity is regulated by growth factors,
nutrients, and cell- cell and cell- matrix ... targeted therapy of cancer.
Therapeutic Approaches to Cell Cycle Abnormalities in Cancer
The mechanism of cell division is substantially the same in all dividing
cells...
Chapter 080. Cancer Cell Biology and Angiogenesis (Part 3) ppt
... before the clinical utility of this approach can be fully realized.
Chapter 080. Cancer Cell Biology
and Angiogenesis
(Part 3)
Figure 80-1
... other stimuli, and predisposes
cells to chromosome instability. This genomic instability greatly increases the
probability that p53 null cells will acquire additional mutations and become
malignant. ... transcription...
Chapter 080. Cancer Cell Biology and Angiogenesis (Part 4) ppsx
... melanoma, prostate, lung, breast, and colon
cancer cells in vitro. Clinical trials of telomerase vaccines are underway.
Chapter 080. Cancer Cell Biology
and Angiogenesis
(Part 4)
Telomerase
DNA ... epithelium, and germ
cells) that require extensive cell division to maintain tissue homeostasis. More
than 90% of human cancers express high levels of telomerase that...
Chapter 080. Cancer Cell Biology and Angiogenesis (Part 5) pps
...
Breast
cancer
Binds HER2 on
tumor cell surface and
induces receptor
internalization.
Cetuximab
(Erbitux)
EGFR Colon
cancer,
squamous cell
carcinoma of the
head and neck
Binds
extracellular ...
Possible activity
against BRAF in
melanoma, colon
cancer, and others.
Erlotinib
(Tarceva)
EGFR Non-
small cell lung
cancer;
pancreatic
cancer
Competitive
inhibit...
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