Chapter 080 Cancer Cell Biology and Angiogenesis (Part 14) doc

... as VEGF and angiopoietins (see below), tumor vessels are tortuous and dilated with an uneven Chapter 080. Cancer Cell Biology and Angiogenesis (Part 14) Oncogene Addiction and Synthetic ... addiction and synthetic lethality have spurred new drug development targeting oncogene and tumor-suppressor pathways. As discussed earlier in this chapter and out...

Ngày tải lên: 07/07/2014, 01:20

... the cancer cell, without harming normal cells (which maintain wild-type function for gene A). High- throughput screens can now be performed using isogenic cell line pairs in which one cell ... transition and passage through the cell cycle. Inhibition of one pathway (such as pathway A by a targeted inhibitor) has no significant effect due to redundancy provi ded by pathways B...

Ngày tải lên: 07/07/2014, 01:20

... the onl y target for proteasome inhibitors. Chapter 080. Cancer Cell Biology and Angiogenesis (Part 10) Estrogen receptors (ERs) and androgen receptors, members of the steroid hormone ... used to treat breast and prostate cancers, respectively. Tamoxifen, a partial agonist and antagonist of ER function, can mediate tumor regression in metastatic breast cance...

Ngày tải lên: 07/07/2014, 01:20

... Chapter 080. Cancer Cell Biology and Angiogenesis (Part 15) Tumor angiogenesis is a complex process involving many different cell types that must proliferate, migrate, invade, and differentiate ... tortuous, dilated, leaky, and extracellular matrix and mediate endothelial cells adhesion, migration, and invasion. Endothelial cells (ECs) also express RTK (i....

Ngày tải lên: 07/07/2014, 01:20

... Chapter 080. Cancer Cell Biology and Angiogenesis (Part 18) Antiangiogenic Therapy Understanding the molecular mechanisms that regulate tumor angiogenesis may provide ... with advanced colon, lung, and breast cancers, and in the second-line treatment of colon cancer. However, not all trials have been positive; in previously treated breast cancer, the addition o...

Ngày tải lên: 07/07/2014, 01:20

... synthesis and mitosis and in response to environmental mutagens; these repair pathways are often abnormal in cancer cells. When a normal cell has sustained too much damage to repair, the cell activates ... damage to the organ. These cell death pathways are also commonly altered in cancer cells, leading to the survival of damaged cells that would normally die. Cancer cells...

Ngày tải lên: 07/07/2014, 01:20

... whether a cell will enter S-phase. The complex of CDK4 or CDK6 with D type cyclins forms a G 1 -specific kinase whose activity is regulated by growth factors, nutrients, and cell- cell and cell- matrix ... targeted therapy of cancer. Therapeutic Approaches to Cell Cycle Abnormalities in Cancer The mechanism of cell division is substantially the same in all dividing cells...

Ngày tải lên: 07/07/2014, 01:20

... before the clinical utility of this approach can be fully realized. Chapter 080. Cancer Cell Biology and Angiogenesis (Part 3) Figure 80-1 ... other stimuli, and predisposes cells to chromosome instability. This genomic instability greatly increases the probability that p53 null cells will acquire additional mutations and become malignant. ... transcription...

Ngày tải lên: 07/07/2014, 01:20

... melanoma, prostate, lung, breast, and colon cancer cells in vitro. Clinical trials of telomerase vaccines are underway. Chapter 080. Cancer Cell Biology and Angiogenesis (Part 4) Telomerase DNA ... epithelium, and germ cells) that require extensive cell division to maintain tissue homeostasis. More than 90% of human cancers express high levels of telomerase that...

Ngày tải lên: 07/07/2014, 01:20

... Breast cancer Binds HER2 on tumor cell surface and induces receptor internalization. Cetuximab (Erbitux) EGFR Colon cancer, squamous cell carcinoma of the head and neck Binds extracellular ... Possible activity against BRAF in melanoma, colon cancer, and others. Erlotinib (Tarceva) EGFR Non- small cell lung cancer; pancreatic cancer Competitive inhibit...

Ngày tải lên: 07/07/2014, 01:20