Chapter 080 Cancer Cell Biology and Angiogenesis (Part 13) pdf
Chapter 080. Cancer Cell Biology and Angiogenesis (Part 13) pdf
... population of stem cells. Cancer stem cells, like
their normal counterparts, have unlimited proliferative capacity and paradoxically
traverse the cell cycle at a very slow rate; cancer growth occurs ... Bcl-2 family
members and drug efflux pumps of the MDR family, render cancer stem cells less
vulnerable to cancer chemotherapy or radiation therapy. Implicit in the cancer...
Chapter 080. Cancer Cell Biology and Angiogenesis (Part 8) pdf
... that may include growth arrest,
differentiation, or apoptosis.
Chapter 080. Cancer Cell Biology
and Angiogenesis
(Part 8)
PI3K is a heterodimeric lipid kinase that catalyses the conversion ... of Myc, β-catenin, cyclin D1,
and cyclin E, and blocking upregulation of p27
Kip1
and Bim (an apoptosis-inducing
protein). Furthermore, the growth of cancer cells requ...
Chapter 080. Cancer Cell Biology and Angiogenesis (Part 20) pdf
...
antibodies, small peptide inhibitors of integrin signaling, and arg-gly-asp-
Chapter 080. Cancer Cell Biology
and Angiogenesis
(Part 20)
The bevacizumab experience suggests that inhibition ...
machinery. Cancer Res 67:2908, 2007 [PMID: 17409392]
Ferrara N, Kerbel RS: Angiogenesis as a therapeutic target. Nature
438:967, 2005 [PMID: 16355214]
Finkel T et al: The...
Chapter 080. Cancer Cell Biology and Angiogenesis (Part 1) pps
... synthesis and mitosis and in response to environmental
mutagens; these repair pathways are often abnormal in cancer cells. When a
normal cell has sustained too much damage to repair, the cell activates ... damage to the organ. These cell death pathways are also
commonly altered in cancer cells, leading to the survival of damaged cells that
would normally die. Cancer cells...
Chapter 080. Cancer Cell Biology and Angiogenesis (Part 2) ppsx
...
whether a cell will enter S-phase. The complex of CDK4 or CDK6 with D type
cyclins forms a G
1
-specific kinase whose activity is regulated by growth factors,
nutrients, and cell- cell and cell- matrix ... targeted therapy of cancer.
Therapeutic Approaches to Cell Cycle Abnormalities in Cancer
The mechanism of cell division is substantially the same in all dividing
cells...
Chapter 080. Cancer Cell Biology and Angiogenesis (Part 3) ppt
... before the clinical utility of this approach can be fully realized.
Chapter 080. Cancer Cell Biology
and Angiogenesis
(Part 3)
Figure 80-1
... other stimuli, and predisposes
cells to chromosome instability. This genomic instability greatly increases the
probability that p53 null cells will acquire additional mutations and become
malignant. ... transcription...
Chapter 080. Cancer Cell Biology and Angiogenesis (Part 4) ppsx
... melanoma, prostate, lung, breast, and colon
cancer cells in vitro. Clinical trials of telomerase vaccines are underway.
Chapter 080. Cancer Cell Biology
and Angiogenesis
(Part 4)
Telomerase
DNA ... epithelium, and germ
cells) that require extensive cell division to maintain tissue homeostasis. More
than 90% of human cancers express high levels of telomerase that...
Chapter 080. Cancer Cell Biology and Angiogenesis (Part 5) pps
...
Breast
cancer
Binds HER2 on
tumor cell surface and
induces receptor
internalization.
Cetuximab
(Erbitux)
EGFR Colon
cancer,
squamous cell
carcinoma of the
head and neck
Binds
extracellular ...
Possible activity
against BRAF in
melanoma, colon
cancer, and others.
Erlotinib
(Tarceva)
EGFR Non-
small cell lung
cancer;
pancreatic
cancer
Competitive
inhibit...
Chapter 080. Cancer Cell Biology and Angiogenesis (Part 6) potx
... of tumor cells and induces
internalization of the receptor, thereby reducing the level of surface expression.
This leads to inhibition of cell cycle progression and renders cancer cells more ...
breast cancer patients.
The PDGFR and its ligand, platelet-derived growth factor (PDGF), are
overexpressed in many glioblastomas and in subsets of melanoma, ovarian,
pancreatic, ga...
Chapter 080. Cancer Cell Biology and Angiogenesis (Part 7) docx
... the cancer cell, without
harming normal cells (which maintain wild-type function for gene A). High-
throughput screens can now be performed
using isogenic cell line pairs in which
one cell ... transition and passage through the cell cycle. Inhibition of one pathway
(such as pathway A by a targeted inhibitor) has no significant effect due to
redundancy provi
ded by pathways B...
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