Chapter 079 Cancer Genetics (Part 9) pot

... respectively. Viruses are not sufficient for cancer development but constitute one alteration in the multistep process of cancer. Chapter 079. Cancer Genetics (Part 9) Chromosomal Instability in Solid ... mutually exclusive in colon cancer, suggesting that they represent alternative mechanisms for the generation of a mutator phenotype in this cancer (Fig. 79-2). Other...

Ngày tải lên: 07/07/2014, 01:20

... Chapter 079. Cancer Genetics (Part 2) General Classes of Cancer Genes There are two major classes of cancer genes. The first class comprises genes ... formulated the two-hit hypothesis, which in its modern version states that both copies of a tumor-suppressor gene must be inactivated in cancer. The second class of cancer genes, the caretakers, ... first hypothesized...

Ngày tải lên: 07/07/2014, 01:20

... progression of cancer. Noncytogenetic, molecular techniques for identifying amplifications have more recently become available. Numerous genes have been reported to be amplified in cancer. Several ... extends to hundreds of thousands of base pairs, more than one oncogene may be amplified in some cancers (particularly sarcomas). Genes simultaneously amplified in many cases include MDM2,...

Ngày tải lên: 07/07/2014, 01:20

... malignancies. Figure 79-2 Chapter 079. Cancer Genetics (Part 1) Harrison's Internal Medicine > Chapter 79. Cancer Genetics Cancer Is a Genetic Disease Cancer arises through a series ... consequence of these mutations in tumor cells, is now known as cancer genetics. The Clonal Origin and Multistep Nature of Cancer Nearly all cancers originate from a s...

Ngày tải lên: 07/07/2014, 01:20

... 22q12.2 AD Vestibular schwannoma, meningioma, spine Chapter 079. Cancer Genetics (Part 3) Familial Cancer Syndromes A small fraction of cancers occur in patients with a genetic predisposition. ... Hereditary breast/ovarian cancer BRC A1 BRC A2 17q21 13q12.3 AD Breast, ovarian, colon, prostate Hereditary diffuse gastric cancer CDH 1 16q22 AD Stomach can...

Ngày tải lên: 07/07/2014, 01:20

... length from chromosome to chromosome. Chapter 079. Cancer Genetics (Part 4) Familial adenomatous polyposis (FAP) is a dominantly inherited colon cancer syndrome due to germline mutations ... dinucleotide repeats in the cancers of HNPCC patients. Figure 79-5 Demonstration of microsatellite instability in normal and tumor tissue from hereditary nonpolyposis colon cance...

Ngày tải lên: 07/07/2014, 01:20

... known to be detectable by the assay methods used). Chapter 079. Cancer Genetics (Part 5) While most autosomal dominant inherited cancer syndromes are due to mutations in tumor-suppressor ... Mendelian forms of cancer have taught us much about the mechanisms of growth control, most forms of cancer do not follow simple patterns of inheritance. In many instances (e.g.,...

Ngày tải lên: 07/07/2014, 01:20

... fusion protein with modified function. (Courtesy of ER Fearon and KR Cho.) Chapter 079. Cancer Genetics (Part 8) Table 79-3 Representative Oncogenes at Chromosomal Translocations ... toxicity in patients with CML. Knowledge of genetic alterations in cancer can lead to mechanism-based design and development of cancer drugs. Figure 79-7 Specific translocat...

Ngày tải lên: 07/07/2014, 01:20

... Strausberg RL et al: I n silico analysis of cancer through the Cancer Genome Anatomy Project. Trends Cell Biol 11:S66, 2001 Chapter 079. Cancer Genetics (Part 10) Figure 79-8 ... segregation and cancer: Cutting through the mystery. Nat Rev Cancer 1:109, 2001 [PMID: 11905802] Loeb LA: Mutator phenotype may be required for multistage carcinogenesis. Cancer Res...

Ngày tải lên: 07/07/2014, 01:20

... Chapter 062. Principles of Human Genetics (Part 9) Nucleic Acid Hybridization Nucleic acid hybridization is a fundamental ... determined by hybridization of RNA samples to cDNA or genomic microarrays. This method has tremendous potential in the era of functional genomics and permits comprehensive analyses of gene expression

Ngày tải lên: 07/07/2014, 01:20