Chapter 074 Biology of Obesity (Part 4) ppsx
Chapter 074. Biology of Obesity (Part 4) ppsx
... common forms of obesity.
Figure 74-4
Chapter 074. Biology of Obesity
(Part 4)
SPECIFIC GENETIC SYNDROMES
For many years obesity in rodents has been known to be caused by a
number of distinct ...
hypothalamic receptor that inhibits eating. Heterozygous loss -of- function
mutations of this receptor account for as much as 5% of severe obesity. These five
genet...
Chapter 074. Biology of Obesity (Part 1) ppsx
... role in systemic complications of obesity is an area of active
investigation.
Definition and Measurement
Obesity is a state of excess adipose tissue mass. Although often viewed as
equivalent ... ratio, with a ratio >0.9 in women and >1.0 in men
being abnormal. Many of the most important complications of obesity, such as
insulin resistance, diabetes, hypertension, hyp...
Chapter 074. Biology of Obesity (Part 2) pdf
... (1) resting or basal
metabolic rate; (2) the energy cost of metabolizing and storing food; (3) the
thermic effect of exercise; and (4) adaptive thermogenesis, which varies in
response to chronic ... activity of
BAT is increased by a central action of leptin, acting through the sympathetic
nervous system, which heavily innervates this tissue. In rodents, BAT deficiency
causes o...
Chapter 074. Biology of Obesity (Part 5) docx
... Chapter 074. Biology of Obesity
(Part 5)
Figure 74-5
A central pathway through which leptin acts to regulate ... for hypothalamic mediators of human obesity or
leanness. The tub gene encodes a hypothalamic peptide of unknown function;
mutation of this gene causes late-onset obesity. The fat gene encodes ...
associated with obesity (Table 74-2). Although specif...
Chapter 074. Biology of Obesity (Part 6) ppt
... that is in the
Chapter 074. Biology of Obesity
(Part 6)
OTHER SPECIFIC SYNDROMES ASSOCIATED WITH OBESITY
Cushing's Syndrome
Although obese patients commonly have central obesity, hypertension, ...
PATHOGENESIS OF COMMON OBESITY
Obesity can result from increased energy intake, decreased energy
expenditure, or a combination of the two. Thus, identifying the e...
Chapter 074. Biology of Obesity (Part 7) ppt
... sensitivity and often improve glucose control in diabetes.
Chapter 074. Biology of Obesity
(Part 7)
WHAT IS THE STATE OF ENERGY EXPENDITURE IN
OBESITY?
The average total daily energy expenditure ...
Pathologic Consequences of Obesity
(See also Chap. 75) Obesity has major adverse effects on health. Obesity is
associated with an increase in mortality, with a 50–10...
Chapter 075. Evaluation and Management of Obesity (Part 4) pptx
... specializing in obesity care.
Chapter 075. Evaluation and
Management of Obesity
(Part 4)
Lifestyle Management
Obesity care involves attention to three essential elements of lifestyle: ...
released by the Institute of Medicine recommends 45–65% of calories from
Another dietary approach to consider is the concept of energy density,
which refers to the number of...
Chapter 075. Evaluation and Management of Obesity (Part 7) ppsx
... Lifestyle modification for the management of obesity.
Gastroenterology 132(6):2226, 2007 [PMID: 17498514]
Chapter 075. Evaluation and
Management of Obesity
(Part 7)
The three restrictive-malabsorptive ... Association for
the Study of Obesity: Practical guide: Identification, evaluation, and treatment of
overweight and obesity in adults. Bethesda, MD, National...
Chapter 080. Cancer Cell Biology and Angiogenesis (Part 4) ppsx
... Clinical trials of telomerase vaccines are underway.
Chapter 080. Cancer Cell Biology
and Angiogenesis
(Part 4)
Telomerase
DNA polymerase is unable to replicate the tips of chromosomes, ... cell cycle machinery (CDKs
and cyclins). Inhibitors of many of these pathways have been developed for the
treatment of human cancers. Examples of inhibitors that are currently...
Chapter 048. Acidosis and Alkalosis (Part 4) ppsx
...
absence of an acid-base disturbance. For instance, an alcoholic who has been
vomiting may develop a metabolic alkalosis with a pH of 7.55, Pa
CO2
of 48
mmHg, [HCO
3
–
] of 40 mmol/L, [Na
+
] of ... with change in [Na
+
].
Calculate the Anion Gap
All evaluations of acid-base disorders should include a simple calculation
of the AG; it represents those unmeasured anions in p...
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