Chapter 065 Gene Therapy in Clinical Medicine (Part 5) ppt

... 17625516] Gene Therapy Clinical Trials Worldwide. J Gene Med, New Jersey, Wiley, 2006 www.abedia.com/wiley/indications.php Chapter 065. Gene Therapy in Clinical Medicine (Part 5) Other ... Sadelain M et al: Targeting tumours with genetically enhance d T lymphocytes. Nat Rev Cancer 3:35, 2003 [PMID: 12509765] Shah PB, Losordo DW: Non- viral vectors for...

Ngày tải lên: 07/07/2014, 01:20

... constitutive expression of angiogenesis inhibitors such as angiostatin and endostatin; use of siRNA to reduce levels of Chapter 065. Gene Therapy in Clinical Medicine (Part 4) Another local ... immune-enhancing genes encoding cytokines, chemokines, or co-stimulatory molecules. Sustained clinical responses provide evidence that the transduced cells can act as a vaccine....

Ngày tải lên: 07/07/2014, 01:20

... No Chapter 065. Gene Therapy in Clinical Medicine (Part 1) Harrison's Internal Medicine > Chapter 65. Gene Therapy in Clinical Medicine Gene Therapy in Clinical Medicine: Introduction ... cells gene transfer in transduced tissues effective in transducing various tissues few inflammatory responses, nonpathogenic gene expressi...

Ngày tải lên: 07/07/2014, 01:20

... complex involved in Chapter 065. Gene Therapy in Clinical Medicine (Part 2) Figure 65-1 Indications in gene therapy clinical trials. The chart divides clinical gene transfer studies by ... J Gene Med. New Jersey, Wiley, 2006.) Gene Transfer for Genetic Disease Gene transfer strategies for genetic disease generally involve gene addition therapy....

Ngày tải lên: 07/07/2014, 01:20

... (VEGF) inhibitors such as angiostatin, or through the use of RNAi-mediated Chapter 065. Gene Therapy in Clinical Medicine (Part 3) Long-Term Expression in Genetic Disease: In Vivo Gene Transfer ... by mutations in several different genes; ~15% of cases of LCA are due to a mutation in a gene, RPE65, encoding a retinal pigment epithelial protein. In dogs with...

Ngày tải lên: 07/07/2014, 01:20

... patients Chapter 003. Decision-Making in Clinical Medicine (Part 5) Economic Incentives Economic incentives are closely related to the other two categories of practice-modifying factors. Financial ... understanding of the patient's problem qualifies as a diagnostic test. Thus, even the history and physical examination can be considered a form of diagnostic test. In...

Ngày tải lên: 06/07/2014, 08:20

... disease is the underlying cause. The absence of a resting Chapter 003. Decision-Making in Clinical Medicine (Part 3) Diagnostic Hypothesis Generation Cognitive scientists studying the thought ... make teaching diagnostic reasoning difficult is that expert clinicians do not follow a fixed pattern in patient examinations. From the outset, they are generating, refining, and d...

Ngày tải lên: 06/07/2014, 08:20

... 064. The Practice of Genetics in Clinical Medicine (Part 5) Molecular analysis is generally more informative if testing is initiated in a symptomatic family member, since the identification ... in preparing pretest educational strategies. Often, patients harbor unwarranted fear or denial of their likelihood of genetic risk. Genetic testing has the potential of affecting...

Ngày tải lên: 07/07/2014, 01:20

... Chapter 003. Decision-Making in Clinical Medicine (Part 1) Harrison's Internal Medicine > Chapter 3. Decision-Making in Clinical Medicine Decision-Making in Clinical Medicine: ... Uncertainty is compounded by the information overload that characterizes modern medicine. Today's experienced clinician needs close to 2 million pieces of information...

Ngày tải lên: 06/07/2014, 08:20

... Chapter 003. Decision-Making in Clinical Medicine (Part 2) The following three examples introduce the subject of clinical reasoning:  A 46-year-old man presents to his internist ... therefore more influential on clinical judgments. The third commonly used cognitive shortcut, the anchoring heuristic, involves estimating a probability by starting from a familiar point (th...

Ngày tải lên: 06/07/2014, 08:20