Chapter 065 Gene Therapy in Clinical Medicine (Part 4) ppt
Chapter 065. Gene Therapy in Clinical Medicine (Part 4) ppt
... constitutive expression of angiogenesis inhibitors such as angiostatin and endostatin; use of siRNA to reduce levels of Chapter 065. Gene Therapy in Clinical Medicine (Part 4) Another local approach ... immune-enhancing genes encoding cytokines, chemokines, or co-stimulatory molecules. Sustained clinical responses provide evidence that the transduced cells can act as a vaccine. In a related ... transduced with genes encoding a T cell receptor–like molecule, with a tumor antigen–binding domain fused to an intracellular signaling domain to allow T cell activation, thereby converting normal...
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Chapter 065. Gene Therapy in Clinical Medicine (Part 5) ppt
... 17625516] Gene Therapy Clinical Trials Worldwide. J Gene Med, New Jersey, Wiley, 2006 www.abedia.com/wiley/indications.php Chapter 065. Gene Therapy in Clinical Medicine (Part 5) ... Sadelain M et al: Targeting tumours with genetically enhanced T lymphocytes. Nat Rev Cancer 3:35, 2003 [PMID: 12509765] Shah PB, Losordo DW: Non-viral vectors for gene therapy: Clinical ... Further Readings Hacein-Bey-Abina S et al: LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-XI. Science 302:415, 2003 [PMID: 14564000] Lin E, Nemunaitis...
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Chapter 065. Gene Therapy in Clinical Medicine (Part 1) doc
... No Chapter 065. Gene Therapy in Clinical Medicine (Part 1) Harrison's Internal Medicine > Chapter 65. Gene Therapy in Clinical Medicine Gene Therapy in Clinical Medicine: Introduction ... cells gene transfer in transduced tissues effective in transducing various tissues few inflammatory responses, nonpathogenic gene expression in both dividing and nondividing cells ... a cell is an inefficient process, most gene transfer is carried out using a vector, or gene delivery vehicle. These vehicles have generally been engineered from viruses by deleting some or all...
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Chapter 065. Gene Therapy in Clinical Medicine (Part 2) pdf
... complex involved in Chapter 065. Gene Therapy in Clinical Medicine (Part 2) Figure 65-1 Indications in gene therapy clinical trials. The chart divides clinical gene transfer studies by ... J Gene Med. New Jersey, Wiley, 2006.) Gene Transfer for Genetic Disease Gene transfer strategies for genetic disease generally involve gene addition therapy. This approach most commonly involves ... first convincing therapeutic effect from gene transfer occurred with X-linked severe combined immunodeficiency disease (SCID), which results from mutations in the gene (IL2RG) encoding the γc...
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Chapter 065. Gene Therapy in Clinical Medicine (Part 3) docx
... (VEGF) inhibitors such as angiostatin, or through the use of RNAi-mediated Chapter 065. Gene Therapy in Clinical Medicine (Part 3) Long-Term Expression in Genetic Disease: In Vivo Gene Transfer ... by mutations in several different genes; ~15% of cases of LCA are due to a mutation in a gene, RPE65, encoding a retinal pigment epithelial protein. In dogs with a null mutation in RPE65, sight ... be achieved even in the absence of integration. Clinical trials using recombinant AAV vectors are now ongoing for muscular dystrophies, α1-antitrypsin deficiency, lipoprotein lipase deficiency,...
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Chapter 003. Decision-Making in Clinical Medicine (Part 3) ppt
... disease is the underlying cause. The absence of a resting Chapter 003. Decision-Making in Clinical Medicine (Part 3) Diagnostic Hypothesis Generation Cognitive scientists studying the thought ... make teaching diagnostic reasoning difficult is that expert clinicians do not follow a fixed pattern in patient examinations. From the outset, they are generating, refining, and discarding diagnostic ... examiner to the exclusion of all other inputs until answered, allowing the examiner to move on to the next specific question. Negative findings are often as important as positive ones in establishing...
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Chapter 003. Decision-Making in Clinical Medicine (Part 4) doc
... (including dosages and side effects), and are less likely to overreact to foreseeable problems in therapy such as a rise in creatinine levels or symptomatic hypotension. Other intriguing research ... influence this role include the physician's knowledge, training, and experience. It is obvious that physicians cannot practice evidence-based medicine (EBM; described later in the chapter) if ... inhibitor therapy in their heart failure patients because they are more familiar with what the targets are (as defined by large clinical trials), have more familiarity with the specific drugs (including...
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Chapter 003. Decision-Making in Clinical Medicine (Part 5) pptx
... patients Chapter 003. Decision-Making in Clinical Medicine (Part 5) Economic Incentives Economic incentives are closely related to the other two categories of practice-modifying factors. Financial ... understanding of the patient's problem qualifies as a diagnostic test. Thus, even the history and physical examination can be considered a form of diagnostic test. In clinical medicine, it ... can exert both stimulatory and inhibitory influences on clinical practice. In general, physicians are paid on a fee-for-service, capitation, or salary basis. In fee-for-service, the more the...
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Chapter 003. Decision-Making in Clinical Medicine (Part 1) doc
... Chapter 003. Decision-Making in Clinical Medicine (Part 1) Harrison's Internal Medicine > Chapter 3. Decision-Making in Clinical Medicine Decision-Making in Clinical Medicine: ... Uncertainty is compounded by the information overload that characterizes modern medicine. Today's experienced clinician needs close to 2 million pieces of information to practice medicine. ... Despite the great technological advances of medicine over the last century, uncertainty still plays a pivotal role in all aspects of medical decision-making. We may know that a patient does not...
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Chapter 003. Decision-Making in Clinical Medicine (Part 2) pdf
... Chapter 003. Decision-Making in Clinical Medicine (Part 2) The following three examples introduce the subject of clinical reasoning: A 46-year-old man presents to his internist ... therefore more influential on clinical judgments. The third commonly used cognitive shortcut, the anchoring heuristic, involves estimating a probability by starting from a familiar point (the anchor) ... the sort encountered daily in clinical medicine, with great efficiency. Clinicians rely on three basic types of heuristics. When assessing a particular patient, clinicians often weigh the probability...
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