Chapter 065 Gene Therapy in Clinical Medicine (Part 2) pdf

... complex involved in Chapter 065. Gene Therapy in Clinical Medicine (Part 2) Figure 65-1 Indications in gene therapy clinical trials. The chart divides clinical gene transfer studies by ... J Gene Med. New Jersey, Wiley, 2006.) Gene Transfer for Genetic Disease Gene transfer strategies for genetic disease generally involve gene addition therap...

Ngày tải lên: 07/07/2014, 01:20

... No Chapter 065. Gene Therapy in Clinical Medicine (Part 1) Harrison's Internal Medicine > Chapter 65. Gene Therapy in Clinical Medicine Gene Therapy in Clinical Medicine: Introduction ... cells gene transfer in transduced tissues effective in transducing various tissues few inflammatory responses, nonpathogenic gene expressi...

Ngày tải lên: 07/07/2014, 01:20

... (VEGF) inhibitors such as angiostatin, or through the use of RNAi-mediated Chapter 065. Gene Therapy in Clinical Medicine (Part 3) Long-Term Expression in Genetic Disease: In Vivo Gene Transfer ... by mutations in several different genes; ~15% of cases of LCA are due to a mutation in a gene, RPE65, encoding a retinal pigment epithelial protein. In dogs with...

Ngày tải lên: 07/07/2014, 01:20

... constitutive expression of angiogenesis inhibitors such as angiostatin and endostatin; use of siRNA to reduce levels of Chapter 065. Gene Therapy in Clinical Medicine (Part 4) Another local ... immune-enhancing genes encoding cytokines, chemokines, or co-stimulatory molecules. Sustained clinical responses provide evidence that the transduced cells can act as a vaccine....

Ngày tải lên: 07/07/2014, 01:20

... 17625516] Gene Therapy Clinical Trials Worldwide. J Gene Med, New Jersey, Wiley, 2006 www.abedia.com/wiley/indications.php Chapter 065. Gene Therapy in Clinical Medicine (Part 5) ... Sadelain M et al: Targeting tumours with genetically enhance d T lymphocytes. Nat Rev Cancer 3:35, 2003 [PMID: 12509765] Shah PB, Losordo DW: Non- viral vectors for gene th...

Ngày tải lên: 07/07/2014, 01:20

... Chapter 003. Decision-Making in Clinical Medicine (Part 2) The following three examples introduce the subject of clinical reasoning:  A 46-year-old man presents to his internist ... therefore more influential on clinical judgments. The third commonly used cognitive shortcut, the anchoring heuristic, involves estimating a probability by starting from a familiar point (...

Ngày tải lên: 06/07/2014, 08:20

... Chapter 003. Decision-Making in Clinical Medicine (Part 1) Harrison's Internal Medicine > Chapter 3. Decision-Making in Clinical Medicine Decision-Making in Clinical Medicine: ... Uncertainty is compounded by the information overload that characterizes modern medicine. Today's experienced clinician needs close to 2 million pieces of information...

Ngày tải lên: 06/07/2014, 08:20

... disease is the underlying cause. The absence of a resting Chapter 003. Decision-Making in Clinical Medicine (Part 3) Diagnostic Hypothesis Generation Cognitive scientists studying the thought ... make teaching diagnostic reasoning difficult is that expert clinicians do not follow a fixed pattern in patient examinations. From the outset, they are generating, refining, and d...

Ngày tải lên: 06/07/2014, 08:20

... (including dosages and side effects), and are less likely to overreact to foreseeable problems in therapy such as a rise in creatinine levels or symptomatic hypotension. Other intriguing research ... influence this role include the physician's knowledge, training, and experience. It is obvious that physicians cannot practice evidence-based medicine (EBM; described later in...

Ngày tải lên: 06/07/2014, 08:20

... patients Chapter 003. Decision-Making in Clinical Medicine (Part 5) Economic Incentives Economic incentives are closely related to the other two categories of practice-modifying factors. Financial ... understanding of the patient's problem qualifies as a diagnostic test. Thus, even the history and physical examination can be considered a form of diagnostic test. In...

Ngày tải lên: 06/07/2014, 08:20