Chapter 065 Gene Therapy in Clinical Medicine (Part 1) doc

... No Chapter 065. Gene Therapy in Clinical Medicine (Part 1) Harrison's Internal Medicine > Chapter 65. Gene Therapy in Clinical Medicine Gene Therapy in Clinical Medicine: Introduction ... cells gene transfer in transduced tissues effective in transducing various tissues few inflammatory responses, nonpathogenic gene expres...

Ngày tải lên: 07/07/2014, 01:20

... (VEGF) inhibitors such as angiostatin, or through the use of RNAi-mediated Chapter 065. Gene Therapy in Clinical Medicine (Part 3) Long-Term Expression in Genetic Disease: In Vivo Gene Transfer ... by mutations in several different genes; ~15% of cases of LCA are due to a mutation in a gene, RPE65, encoding a retinal pigment epithelial protein. In dogs with...

Ngày tải lên: 07/07/2014, 01:20

... complex involved in Chapter 065. Gene Therapy in Clinical Medicine (Part 2) Figure 65-1 Indications in gene therapy clinical trials. The chart divides clinical gene transfer studies by ... J Gene Med. New Jersey, Wiley, 2006.) Gene Transfer for Genetic Disease Gene transfer strategies for genetic disease generally involve gene addition therapy....

Ngày tải lên: 07/07/2014, 01:20

... constitutive expression of angiogenesis inhibitors such as angiostatin and endostatin; use of siRNA to reduce levels of Chapter 065. Gene Therapy in Clinical Medicine (Part 4) Another local ... immune-enhancing genes encoding cytokines, chemokines, or co-stimulatory molecules. Sustained clinical responses provide evidence that the transduced cells can act as a vaccine....

Ngày tải lên: 07/07/2014, 01:20

... 17625516] Gene Therapy Clinical Trials Worldwide. J Gene Med, New Jersey, Wiley, 2006 www.abedia.com/wiley/indications.php Chapter 065. Gene Therapy in Clinical Medicine (Part 5) ... Sadelain M et al: Targeting tumours with genetically enhance d T lymphocytes. Nat Rev Cancer 3:35, 2003 [PMID: 12509765] Shah PB, Losordo DW: Non- viral vectors for gene th...

Ngày tải lên: 07/07/2014, 01:20

... Chapter 003. Decision-Making in Clinical Medicine (Part 1) Harrison's Internal Medicine > Chapter 3. Decision-Making in Clinical Medicine Decision-Making in Clinical Medicine: ... Uncertainty is compounded by the information overload that characterizes modern medicine. Today's experienced clinician needs close to 2 million pieces of informatio...

Ngày tải lên: 06/07/2014, 08:20

... (including dosages and side effects), and are less likely to overreact to foreseeable problems in therapy such as a rise in creatinine levels or symptomatic hypotension. Other intriguing research ... influence this role include the physician's knowledge, training, and experience. It is obvious that physicians cannot practice evidence-based medicine (EBM; described later in...

Ngày tải lên: 06/07/2014, 08:20

... predictive value is best avoided in favor of the more informative posttest probability. Chapter 003. Decision-Making in Clinical Medicine (Part 6) Calculating sensitivity and specificity ... response in a treadmill exercise test) to the exclusion of other potentially relevant data. In addition, ROC area comparisons do not simulate the way test information is actually u...

Ngày tải lên: 06/07/2014, 08:20

... whereas test specificity will be higher in outpatients. times more likely in a patient with the disease than in a patient without it. Most tests in medicine have likelihood ratios for a positive ... finding of a reversible exercise-induced perfusion defect has both a sensitivity and specificity of 90%, yielding a likelihood ratio for a positive test of 9.0 [0.90/(1 – 0.90)]. I...

Ngày tải lên: 06/07/2014, 08:20

... considered, their relevant Chapter 003. Decision-Making in Clinical Medicine (Part 8) Statistical Prediction Models Bayes' theorem, as presented above, deals with a clinical prediction problem ... early therapy of HIV infection and the prevalence and incidence of HIV infection in the population targeted. This model, which required over 75 separate data points, pr...

Ngày tải lên: 06/07/2014, 08:20