... applied to all but the largest genes (Fig. 62- 14). Figure 62-14 Chapter 062. Principles of Human Genetics (Part 29) Population Genetics In population genetics, the focus changes from alterations ... with p2 corresponding to the frequency of AA, 2pq to the frequency of Aa, and q2 to aa. When the frequency of an allele is known, the frequency of the genotype can be calculated. Alternatively, ... detection, genetic counseling, early intervention, and prevention of a disease in relatives of the index patient (Chap. 64). In instances where a diagnosis at the molecular level may be relevant,...