Chapter 059 Bleeding and Thrombosis (Part 5) ppt
Chapter 059. Bleeding and Thrombosis (Part 5) ppt
...
Chapter 059. Bleeding and Thrombosis
(Part 5)
Epistaxis is a common symptom, particularly in children and in dry
climates, and may not reflect an underlying bleeding disorder. ... hereditary hemorrhagic telangiectasia and in boys with
vWD. Clues that epistaxis is a symptom of an underlying bleeding disorder
include lack of seasonal variation and bleeding tha...
Chapter 059. Bleeding and Thrombosis (Part 7) pptx
... to the
threshold for thrombosis and result in deep venous thrombosis (DVT). Note: The
magnitude and duration of risk portrayed in the figure is meant for example only
and may not precisely ...
Venous thrombosis: A multicausal disease. Lancet 353:1167, 1999.]
Laboratory Evaluation
Careful history taking and clinical examination are essential components in
the assessment of...
Chapter 059. Bleeding and Thrombosis (Part 8) pptx
... abnormalities is shown in Table 59-4.
Chapter 059. Bleeding and Thrombosis
(Part 8)
Screening Assays
The most commonly used screening tests are the PT, aPTT, and platelet
count. The PT assesses ... reagents to clotting factor deficiencies and to
inhibitors such as heparin and lupus anticoagulants. Thus, aPTT results will vary
from one laboratory to another, and the...
Chapter 059. Bleeding and Thrombosis (Part 1) pdf
...
Chapter 059. Bleeding and Thrombosis
(Part 1)
Harrison's Internal Medicine > Chapter 59. Bleeding and Thrombosis
Bleeding and Thrombosis: Introduction
The ...
procoagulant and anticoagulant forces. The procoagulant forces include platelet
adhesion and aggregation and fibrin clot formation; anticoagulant forces include
the natural inhibitors of...
Chapter 059. Bleeding and Thrombosis (Part 2) potx
... factor) to factor XIIIa, which covalently cross-links and thereby
stabilizes the fibrin clot.
Figure 59-2
Chapter 059. Bleeding and Thrombosis
(Part 2)
Coagulation is initiated by tissue factor ... FIX and FX, which in turn, with FVIII and FV as
cofactors, respectively, results in thrombin formation and subsequent conversion
of fibrinogen to fibrin. Thrombin activa...
Chapter 059. Bleeding and Thrombosis (Part 3) docx
... Chapter 059. Bleeding and Thrombosis
(Part 3)
Sites of action of the four major physiologic antithrombotic pathways: ...
thrombin and the other clotting factors in coagulation. Antithrombin neutralizes
thrombin and other activated coagulation factors by forming a complex between
the active site of the enzyme and the ... sensitive markers of blood clot formation, and...
Chapter 059. Bleeding and Thrombosis (Part 4) potx
... Chapter 059. Bleeding and Thrombosis
(Part 4)
Approach to the Patient: Bleeding and Thrombosis
Clinical Presentation
Disorders of hemostasis ... contributed to the bleeding or thrombotic state. In addition,
the history can give clues as to the etiology by determining (1) the bleeding
(mucosal and/ or joint) or thrombosis (arterial and/ or venous) ... trauma/s...
Chapter 059. Bleeding and Thrombosis (Part 6) doc
... factor pathway inhibitor.
Chapter 059. Bleeding and Thrombosis
(Part 6)
Underlying Systemic Diseases that Cause or Exacerbate a Bleeding
Tendency
Acquired bleeding disorders are commonly ... obesity, and genetic predispositions. Factors that increase risks for venous
and both venous and arterial thromboses are shown in Table 59-3.
Age Antiphospholipid antibody...
Chapter 059. Bleeding and Thrombosis (Part 9) ppsx
... medications, and the association
between minor defects in aggregation or secretion in these assays and bleeding
risk is not clearly established
Acknowledgment
Robert I. Handin, MD, contributed this chapter ... pregnancy, and medications
affect levels of many coagulation factors and their inhibitors. Antithrombin is
decreased by heparin and in the setting of acute thrombos...
Chapter 022. Dizziness and Vertigo (Part 5) pptx
...
Glucocorticoids
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100
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days,
tapered by
20 mg every
3 days
Chapter 022. Dizziness and Vertigo
(Part 5)
Evaluation of Patients with Pathologic Vestibular Vertigo
The evaluation ...
distinction between organic and psychogenic is uncertain, (2) establish the side of
the abnormality, and (3) distinguish between peripheral and central etiologies. The
stand...