Chapter 056 Cutaneous Drug Reactions (Part 3) docx

... PRESENTATION OF CUTANEOUS DRUG REACTIONS Nonimmune Cutaneous Reactions EXACERBATION OR INDUCTION OF DERMATOLOGIC DISEASES stimulation of T cells by medications leads to reactions that are ... neutrophil-mediated drug reaction. One may therefore assume that the final pattern of drug eruptions results both from the nature of effectors—cytotoxic T cells in blistering reac...

Ngày tải lên: 07/07/2014, 01:20

... in patients receiving cytotoxic drugs can be increased by exposure to sunlight. Chapter 056. Cutaneous Drug Reactions (Part 3) PIGMENTATION CHANGES Drugs, either systemic or topical, ... Development of the syndrome is unrelated to drug dose, and the course is not altered by discontinuation of the drug after onset of the eruption. Warfarin reactions are associated...

Ngày tải lên: 07/07/2014, 01:20

... explained. Chapter 056. Cutaneous Drug Reactions (Part 1) Harrison's Internal Medicine > Chapter 56. Cutaneous Drug Reactions CUTANEOUS DRUG REACTIONS: INTRODUCTION Cutaneous reactions ... adverse cutaneous reactions. INCIDENCE OF CUTANEOUS REACTIONS Several large cohort studies established that acute cutaneous reaction to drugs affected...

Ngày tải lên: 07/07/2014, 01:20

... was frequent in CD4+ clones while CD8+ Chapter 056. Cutaneous Drug Reactions (Part 2) PATHOGENESIS OF DRUG REACTIONS Untoward cutaneous responses to drugs can arise as a result of immunologic ... preventive measures. Immunologic Drug Reactions For most acute drug eruptions, benign or severe, accumulated data suggest an immunologic basis. In the last 10 years...

Ngày tải lên: 07/07/2014, 01:20

... helpful. In addition to drug Chapter 056. Cutaneous Drug Reactions (Part 5) Onychomadesis Onychomadesis is caused by temporary arrest of nail matrix mitotic activity. Common drugs reported to ... rarer in Caucasians. Immune Cutaneous Reactions: Benign MACULOPAPULAR ERUPTIONS Morbilliform or maculopapular eruptions are the most common of all drug- induced reactions...

Ngày tải lên: 07/07/2014, 01:20

... cross -reactions among aromatic anticonvulsants, including phenytoin, carbamazepine, and barbiturates, are frequent. Other drugs causing this syndrome include lamotrigine, Chapter 056. Cutaneous ... causing this syndrome include lamotrigine, Chapter 056. Cutaneous Drug Reactions (Part 7) FIXED DRUG ERUPTIONS These reactions are characterized by one or more sharply...

Ngày tải lên: 07/07/2014, 01:20

... subject of many investigations and a model for " ;drug allergy." Incidence of cutaneous reactions is about 1%. About 85% of cutaneous reactions to penicillin are morbilliform, and about ... serum. newer, are associated with many types of severe reactions and a high incidence of less severe reactions, particularly in children. These drugs have among the highest risk of...

Ngày tải lên: 07/07/2014, 01:20

... doxorubicin, Chapter 056. Cutaneous Drug Reactions (Part 9) Sulfonamides Antibacterial sulfonamides have a rather high risk of causing cutaneous eruptions and are among the drugs most frequently ... misinterpreted as drug eruptions but are instead drug side effects. Allergy to glucocorticoids may also occur either as contact dermatitis to topical formulations or as s...

Ngày tải lên: 07/07/2014, 01:20

... nephropathies C. Renal water loss 1. Diabetes insipidus (central or nephrogenic) Chapter 046. Sodium and Water (Part 3) Hypovolemia Etiology True volume depletion, or hypovolemia, generally

Ngày tải lên: 06/07/2014, 15:21

... Chapter 059. Bleeding and Thrombosis (Part 3) Sites of action of the four major physiologic antithrombotic pathways: ... inhibitor of plasmin in human plasma, inactivating any nonfibrin clot–associated plasmin. reactions. Inherited quantitative or qualitative deficiencies of antithrombin lead to a lifelong

Ngày tải lên: 07/07/2014, 01:20