Chapter 055 Immunologically Mediated Skin Diseases (Part 2) ppsx
Chapter 055. Immunologically Mediated Skin Diseases (Part 2) ppsx
... lesional or intact patient skin shows deposits of IgG on the surface of keratinocytes; deposits of complement components are typically found in lesional but not uninvolved skin. Deposits of IgG ... produce extensive denudation of the skin (Fig. 55-1). PV typically involves the mouth, scalp, face, neck, axilla, groin, and trunk. PV may be associated with severe skin pain; some patients experience ... membrane, hence blister formation is within the suprabasal portion of the epidermis. Lesional skin may contain focal collections of intraepidermal eosinophils within blister cavities; dermal...
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Chapter 055. Immunologically Mediated Skin Diseases (Part 3) pps
... structure (e.g., penicillamine, captopril, enalapril) are most commonly Chapter 055. Immunologically Mediated Skin Diseases (Part 3) Pemphigus Foliaceus Pemphigus foliaceus (PF) is distinguished ... Castleman's disease; the latter is particularly common among children with PNP. In addition to severe skin lesions, many patients with PNP develop life-threatening bronchiolitis obliterans. PNP is ... features in common with PV. Specifically, direct immunofluorescence microscopy of perilesional skin demonstrates IgG on the surface of keratinocytes. Similarly, patients with PF have circulating...
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Chapter 055. Immunologically Mediated Skin Diseases (Part 4) pdf
... Chapter 055. Immunologically Mediated Skin Diseases (Part 4) Bullous Pemphigoid Bullous pemphigoid (BP) is a polymorphic ... most patients eventually display tense blisters on either normal-appearing or erythematous skin (Fig. 55 -2). The lesions are usually distributed over the lower abdomen, groin, and flexor surface ... lesional skin demonstrate subepidermal blisters and histologic features that roughly correlate with the clinical character of the particular lesion under study. Lesions on normal-appearing skin...
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Chapter 055. Immunologically Mediated Skin Diseases (Part 5) docx
... their skin disease, and is associated with the reappearance of IgA in their epidermal basement membrane zone. As in patients with celiac disease, dietary gluten sensitivity in Chapter 055. Immunologically ... patients with celiac disease, dietary gluten sensitivity in Chapter 055. Immunologically Mediated Skin Diseases (Part 5) Pemphigoid Gestationis Pemphigoid gestationis (PG), also known as herpes ... diagnosis is confirmed by direct immunofluorescence microscopy of normal-appearing perilesional skin. Such studies demonstrate granular deposits of IgA (with or without complement components)...
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Chapter 055. Immunologically Mediated Skin Diseases (Part 6) pdf
... with inflammatory bowel disease (especially Crohn's disease). Chapter 055. Immunologically Mediated Skin Diseases (Part 6) Linear IgA Disease Linear IgA disease, once considered a ... that may be affected include the nasopharyngeal, laryngeal, esophageal, and anogenital mucosa. Skin lesions (present in about one-third of patients) tend to predominate on the scalp, face, and ... for aspiration. Strictures may also complicate anogenital involvement. The histology of lesional skin varies depending on the character of the lesion being studied. Noninflammatory bullae show...
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Chapter 055. Immunologically Mediated Skin Diseases (Part 7) docx
... photoprotective measures such as broad-spectrum sunscreens. Figure 55-3 Chapter 055. Immunologically Mediated Skin Diseases (Part 7) Dermatomyositis The cutaneous manifestations of dermatomyositis ... papules, heliotrope erythema, and poikiloderma serve to distinguish patients with dermatomyositis. Skin biopsy of erythematous, scaling lesions of dermatomyositis may reveal only mild nonspecific ... dermis, and a mild mononuclear cell infiltrate. Direct immunofluorescence microscopy of lesional skin is usually negative, although granular deposits of immunoglobulin(s) and complement in the...
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Chapter 055. Immunologically Mediated Skin Diseases (Part 8) docx
... ineffective, use of aminoquinoline antimalarials may be indicated. Chapter 055. Immunologically Mediated Skin Diseases (Part 8) Lupus Erythematosus The cutaneous manifestations of lupus ... evanescent, usually last for days and are often associated with exacerbations of systemic disease. Skin biopsy of acute lesions may show only a require treatment with aminoquinoline antimalarials. ... degeneration of basal cells of the epidermis. Direct immunofluorescence microscopy of lesional skin frequently reveals deposits of immunoglobulin(s) and complement in the epidermal basement...
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Chapter 055. Immunologically Mediated Skin Diseases (Part 9) doc
... microscopy of lesional skin is usually negative. Figure 55-7 Chapter 055. Immunologically Mediated Skin Diseases (Part 9) Figure 55-6 ... scleroderma. Skin biopsy reveals thickening of the dermis and homogenization of collagen bundles. Direct immunofluorescence microscopy of lesional skin is usually negative. Figure 55-7 Chapter 055. ... Scleroderma and Morphea The skin changes of scleroderma (Chap. 316) usually begin on the hands, feet, and face, with episodes of recurrent nonpitting edema. Sclerosis of the skin begins distally...
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Chapter 055. Immunologically Mediated Skin Diseases (Part 10) pot
... and therapeutic considerations. JAMA 284:350, 2000 [PMID: 10891967] Chapter 055. Immunologically Mediated Skin Diseases (Part 10) Scleroderma often eventuates in development of an expressionless, ... and inherited subepidermal blistering diseases: Advances in the clinic and the laboratory. Adv Dermatol 16:113, 2000 [PMID: 11094626] Sontheimer RD: Skin manifestations of systemic autoimmune ... These skin findings are accompanied by peripheral blood eosinophilia, increased erythrocyte sedimentation rate, and sometimes hypergammaglobulinemia. Deep biopsy of affected areas of skin reveals...
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Chapter 081. Principles of Cancer Treatment (Part 2) ppsx
... with pancolonic involvement with ulcerative colitis), the presence of Chapter 081. Principles of Cancer Treatment (Part 2) Figure 81-1 ... prevented by surgery in people who have premalignant lesions resected (e.g., premalignant lesions of skin, colon, cervix) and in those who are at increased risk of cancer from either an underlying...
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