Chapter 043 Jaundice (Part 1) pptx
Chapter 043. Jaundice (Part 1) pptx
... membrane transport. No specific bilirubin transporter
has yet been identified (Chap. 297, Fig. 297 -1).
After entering the hepatocyte, unconjugated bilirubin is bound to the
cytosolic protein ligandin, ... to biliverdin.
The differential diagnosis for yellowing of the skin is limited. In addition to
jaundice, it includes carotenoderma, the use of the drug quinacrine, and excessive
expos...
Chapter 043. Jaundice (Part 5) pptx
... advanced cirrhosis.
Chapter 043. Jaundice
(Part 5)
History
A complete medical history is perhaps the single most important part of the
evaluation of the patient with unexplained jaundice. Important ... particular diagnosis. A history of arthralgias and myalgias predating jaundice
suggests hepatitis, either viral or drug-related. Jaundice associated with the sudden
onset o...
Chapter 043. Jaundice (Part 9) pot
... Chapter 043. Jaundice
(Part 9)
Choledocholithiasis is the most common cause of extrahepatic cholestasis. ... quadrant discomfort
with only minimal elevations of the enzyme tests to ascending cholangitis with
jaundice, sepsis, and circulatory collapse. PSC may occur with clinically important
strictures ... 800 IU/L), but the bilirubin is often near normal. These patients do
not...
Chapter 043. Jaundice (Part 2) potx
... glucuronides is
impaired and the glucuronides are present in serum in increasing amounts. By
Chapter 043. Jaundice
(Part 2)
Measurement of Serum Bilirubin
The terms direct- and indirect-reacting ... backward leakage of the pigment. The
initial steps in evaluating the patient with jaundice are to determine (1) whether
the hyperbilirubinemia is predominantly conjugated or unc...
Chapter 043. Jaundice (Part 3) ppt
... Direct hyperbilirubinemia
A. Inherited
conditions
1. Dubin-
Chapter 043. Jaundice
(Part 3)
Evaluation of the patient with jaundice. MRCP, magnetic resonance
cholangiopancreatography; ALT, ...
The differential diagnosis of an isolated unconjugated hyperbilirubinemia is
limited (Table 43 -1). The critical determination is whether the patient is suffering
from a hemolytic...
Chapter 043. Jaundice (Part 4) pdf
...
conditions: Dubin-Johnson syndrome and Rotor's syndrome (Table 43 -1). Patients
with both conditions present with asymptomatic jaundice, typically in the second
generation of life. The defect ... nature.
Elevation of Serum Bilirubin with Other Liver Test Abnormalities
The remainder of this chapter will focus on the evaluation of the patient
with a conjugated hyperbilirubinemia i...
Chapter 043. Jaundice (Part 6) pps
...
Wilson's disease
Autoimmune hepatitis
Chapter 043. Jaundice
(Part 6)
Hepatocellular Conditions
Hepatocellular diseases that can cause jaundice include viral hepatitis, drug
or environmental ... believed to occur primarily in young adults, should
be considered in all adults if no other cause of jaundice is found.
Autoimmune hepatitis is typically seen in young...
Chapter 043. Jaundice (Part 7) doc
... Cholestasis of pregnancy
I. Total parenteral nutrition
J. Nonhepatobiliary sepsis
Chapter 043. Jaundice
(Part 7)
Cholestatic Conditions
When the pattern of the liver tests suggests a cholestatic ... disorder, the next
step is to determine whether it is intra- or extrahepatic cholestasis (Fig. 43 -1).
Distinguishing intrahepatic from extrahepatic cholestasis may be difficult....
Chapter 043. Jaundice (Part 8) doc
...
marrow transplantation. Vanishing bile duct syndrome also occurs in rare cases of
Chapter 043. Jaundice
(Part 8)
Drugs may cause intrahepatic cholestasis, a variant of drug-induced
hepatitis. ... the intensive care unit, the major
considerations should be sepsis, shock liver, and TPN jaundice. Jaundice
occurring after bone marrow transplantation is most likely due to venooc...
Chapter 012. Pain: Pathophysiology and Management (Part 1) pptx
... neurons:
primary sensory afferents, motor neurons, and sympathetic postganglionic neurons
(Fig. 12 -1). The cell bodies of primary sensory afferents are located in the dorsal
root ganglia in the ... afferents: the small-diameter myelinated A-
delta (Aδ) and the unmyelinated (C fiber) axons (Fig. 12 -1). These fibers are
present in nerves to the skin and to deep somatic and visceral struct...
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