... therapy (Fig. 5-5A ). Effects of Disease on Drug Concentration and Response Chapter 005. Principles of Clinical Pharmacology (Part 6) Principles of Dose Selection The desired goal of therapy ... levels yielding therapeutic and adverse effects, as with digoxin, theophylline, some antiarrhythmics, aminoglycosides, cyclosporine, and anticonvulsants. On the other hand, if drug access to important ... concentration) and these dual effects and provides a starting point for initiation of drug therapy. Figure 5-1 illustrates the relationships among dose, plasma concentrations, efficacy, and adverse...