Biochemistry, 4th Edition P30 pot
Biochemistry, 4th Edition P30 pot
... subunit.
ᮡ
This substance, also known as I-739,749, is a farnesyl transferase
inhibitor that is a potent tumor growth suppressor.
ᮡ
The farnesylation and subsequent processing of the Ras protein.
Biochemistry, 4th Edition P6 potx
... the intermediates in metabolism.
Mechanical support, shape, and protection against
swelling in hypotonic media. The cell wall is a
porous nonselective barrier that allows most small
molecules to
Biochemistry, 4th Edition P7 pot
... H-bond formation. Water can
serve as both an H donor and an H acceptor in H-bond formation. The potential to
form four H bonds per water molecule is the source of the strong intermolecular at-
tractions ... such structures are the
processes of life. Properties of biomolecules that endow them with the
potential for creating the living state include the following: Biological
macromolecules and...
Biochemistry, 4th Edition P10 potx
... ionization.
[ADP][P
i
]
ᎏᎏ
[ATP][H
2
O]
Ϫ⌬G°
ᎏ
nᏲ
Proton Transfer Potential Standard Reduction Potential Group Transfer Potential
(Acidity) (Electron Transfer Potential) (High-Energy Bond)
Simple equation AH
34
A
Ϫ
ϩ ... (pK
a
and reduction poten-
tial, Ᏹ
o
, respectively). As shown in Table 3.4, the notion of group transfer is fully
analogous to those of ionization potential and reduction po...
Biochemistry, 4th Edition P11 potx
... the reactions necessary to keep cells and organisms alive must run against
their thermodynamic potential, that is, in the direction of positive ⌬G. Among these
are the synthesis of adenosine ... All naturally occurring processes proceed toward equilib-
rium, that is, to a state of minimum potential energy. The third law of
thermodynamics states that the entropy of any crystalline, perfectly
o...
Biochemistry, 4th Edition P19 potx
... together. This hydrophobic effect in-
duces formation of a compact structure—the folded protein.
A potential problem with this rather simple folding model is that polar backbone
NOH and CP
O groups
Biochemistry, 4th Edition P25 pot
... N-linked oligosaccharides to direct selected proteins to
A DEEPER LOOK
Drug Research Finds a Sweet Spot
A variety of diseases are being successfully treated with sugar-based
therapies. As this table ... medicines.Scientific American 287:40–47.
Additional References: Alper, J.,2001. Searching for medicine’s sweet spot. Science 291:2338–2343. Borman,S., 2007. Sugar medicine. Chemical & Engi...
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