Chapter 003 Decision-Making in Clinical Medicine (Part 9) doc
Chapter 003. Decision-Making in Clinical Medicine (Part 9) doc
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Chapter 003. Decision-Making
in Clinical Medicine
(Part 9)
Evidence-Based Medicine
The "art of medicine& quot; ... traditionally defined as a practice combining
medical knowledge (including scientific evidence), intuition, and judgment in the
care of patients (Chap. 1). Evidence-based...
Chapter 003. Decision-Making in Clinical Medicine (Part 1) doc
... Chapter 003. Decision-Making
in Clinical Medicine
(Part 1)
Harrison's Internal Medicine > Chapter 3. Decision-Making in Clinical
Medicine
Decision-Making in Clinical Medicine: ...
Uncertainty is compounded by the information overload that characterizes
modern medicine. Today's experienced clinician needs close to 2 million pieces of
inform...
Chapter 003. Decision-Making in Clinical Medicine (Part 4) doc
... influence this role include the physician's knowledge, training, and
experience. It is obvious that physicians cannot practice evidence-based medicine
(EBM; described later in the chapter) if ... therapy in their heart failure patients because
they are more familiar with what the targets are (as defined by large clinical trials),
have more familiarity with the specific drugs...
Chapter 003. Decision-Making in Clinical Medicine (Part 6) doc
... predictive value is best avoided in favor of the more informative
posttest probability.
Chapter 003. Decision-Making
in Clinical Medicine
(Part 6)
Calculating sensitivity and specificity ... response in a treadmill exercise test)
to the exclusion of other potentially relevant data. In addition, ROC area
comparisons do not simulate the way test information is actuall...
Chapter 003. Decision-Making in Clinical Medicine (Part 7) docx
... whereas test specificity will be higher in outpatients.
times more likely in a patient with the disease than in a patient without it. Most
tests in medicine have likelihood ratios for a positive ... finding of a reversible
exercise-induced perfusion defect has both a sensitivity and specificity of 90%,
yielding a likelihood ratio for a positive test of 9.0 [0.90/(1 – 0.90)]. I...
Chapter 003. Decision-Making in Clinical Medicine (Part 8) docx
... considered, their relevant
Chapter 003. Decision-Making
in Clinical Medicine
(Part 8)
Statistical Prediction Models
Bayes' theorem, as presented above, deals with a clinical prediction
problem ... of HIV infection and the
prevalence and incidence of HIV infection in the population targeted. This model,
which required over 75 separate data points, provides novel...
Chapter 003. Decision-Making in Clinical Medicine (Part 11) docx
... are on an
ACE inhibitor. Routine measurement and reporting of such quality indicators can
Reilly BM et al: Translating clinical research into clinical practice: Impact
of using prediction ... little or no supporting evidence and, thus, reflect the expert
consensus of the guideline panel. In part to protect against errors by individual
panels, the final step in guideline construct...
Chapter 065. Gene Therapy in Clinical Medicine (Part 1) doc
... No
Chapter 065. Gene Therapy in
Clinical Medicine
(Part 1)
Harrison's Internal Medicine > Chapter 65. Gene Therapy in Clinical
Medicine
Gene Therapy in Clinical Medicine: Introduction ... transfer in
dividing cells
gene transfer in
transduced
tissues
effective in
transducing
various tissues
few
inflammatory
responses,
nonpathogenic
gen...
Chapter 065. Gene Therapy in Clinical Medicine (Part 3) docx
... 065. Gene Therapy in
Clinical Medicine
(Part 3)
Long-Term Expression in Genetic Disease: In Vivo Gene Transfer with
Recombinant Adeno-Associated Viral (AAV) Vectors
Recombinant AAV vectors ... by mutations in several different genes; ~15% of cases of LCA
are due to a mutation in a gene, RPE65, encoding a retinal pigment epithelial
protein. In dogs with a null mutati...
Chapter 003. Decision-Making in Clinical Medicine (Part 2) pdf
... Chapter 003. Decision-Making
in Clinical Medicine
(Part 2)
The following three examples introduce the subject of clinical reasoning:
A 46-year-old man presents to his internist ... therefore more influential on clinical judgments.
The third commonly used cognitive shortcut, the anchoring heuristic,
involves estimating a probability by starting from a familiar point...