Chapter 003 Decision-Making in Clinical Medicine (Part 3) ppt

... disease is the underlying cause. The absence of a resting Chapter 003. Decision-Making in Clinical Medicine (Part 3) Diagnostic Hypothesis Generation Cognitive scientists studying the thought ... make teaching diagnostic reasoning difficult is that expert clinicians do not follow a fixed pattern in patient examinations. From the outset, they are generating, refining,...

Ngày tải lên: 06/07/2014, 08:20

... patients Chapter 003. Decision-Making in Clinical Medicine (Part 5) Economic Incentives Economic incentives are closely related to the other two categories of practice-modifying factors. Financial ... understanding of the patient's problem qualifies as a diagnostic test. Thus, even the history and physical examination can be considered a form of diagnostic test. In...

Ngày tải lên: 06/07/2014, 08:20

... family history of cancer. Chapter 064. The Practice of Genetics in Clinical Medicine (Part 3) Recall of family history is often inaccurate. This is especially so when the history is remote ... reported in the family history before making important and, in certain circumstances, irreversible management decisions. This process is often labor intensive and ideally involv...

Ngày tải lên: 07/07/2014, 01:20

... 065. Gene Therapy in Clinical Medicine (Part 3) Long-Term Expression in Genetic Disease: In Vivo Gene Transfer with Recombinant Adeno-Associated Viral (AAV) Vectors Recombinant AAV vectors ... by mutations in several different genes; ~15% of cases of LCA are due to a mutation in a gene, RPE65, encoding a retinal pigment epithelial protein. In dogs with a null muta...

Ngày tải lên: 07/07/2014, 01:20

... dysfunction after spinal cord injury reflects demyelination, and both ES cells and marrow-derived stem cells are able to facilitate remyelination after experimental spinal cord injury. Clinical trials ... for stem cell therapies include spinal cord injury, amyotrophic lateral sclerosis, stroke, traumatic brain injury, Batten disease, and Parkinson's disease. In Parkinson's...

Ngày tải lên: 07/07/2014, 01:20

... role in educating patients about the indications, benefits, risks, and limitations of genetic testing in the management of Chapter 064. The Practice of Genetics in Clinical Medicine (Part ... (Part 1) Harrison's Internal Medicine > Chapter 64. The Practice of Genetics in Clinical Medicine Implications of Molecular Genetics for Internal Medicine Th...

Ngày tải lên: 07/07/2014, 01:20

... documented in the pedigree include the presence or absence of nonhereditary risk factors among those affected with diseases, and the finding of multiple diseases in an individual patient. For instance, ... including grandparents. When pedigrees appear to suggest an inherited disease, they should be extended to include additional family members. The determination of risk for an asympto...

Ngày tải lên: 07/07/2014, 01:20

... The Practice of Genetics in Clinical Medicine (Part 5) Molecular analysis is generally more informative if testing is initiated in a symptomatic family member, since the identification of ... Informed consent for molecular testing begins with detailed education and counseling (Fig. 64 -3). The patient must fully understand the risks, benefits, and limitations of undergoing t...

Ngày tải lên: 07/07/2014, 01:20

... constitutive expression of angiogenesis inhibitors such as angiostatin and endostatin; use of siRNA to reduce levels of Chapter 065. Gene Therapy in Clinical Medicine (Part 4) Another local approach ... encoding a T cell receptor–like molecule, with a tumor antigen–binding domain fused to an intracellular signaling domain to allow T cell activation, thereby converting norma...

Ngày tải lên: 07/07/2014, 01:20

... dopamine, or of the inhibitory neurotransmitter γ-aminobutyric acid, have been introduced into affected areas of the brain (striatum, subthalamic nucleus) by stereotactic neurosurgery. In Alzheimer's ... Jersey, Wiley, 2006 www.abedia.com/wiley/indications.php Chapter 065. Gene Therapy in Clinical Medicine (Part 5) Other Diseases The power and versatility of g...

Ngày tải lên: 07/07/2014, 01:20