Pharmaceutical Substances Syntheses, Patents, Applications - Part 12 pdf

... (111) 4-pyridyl- molonoldehyde 1.2-dihydro- 2-0 x 0- 5-( 4-pyridyl). nicotinic acid 3-nitro- 5-( 4-pyridyl )- Z(1H)-pyridinone (IV) 120 A Anastrozole synthesis of ethyl N-(2,3-dichloro-6-aminobenzy1)glycinate: ... ester 2,3-dkhloro- 6-nitro- benzonitrile ethyl N-(2,3-dichloro- 6- diphenyl N-cyano- ethyl (2-cyonoimino-5, 6- orninobenzyi)glycinote irnidoc...

Ngày tải lên: 02/07/2014, 02:20

... 4-methyl- 2- nitrooniline 3-dimethylomino- 7- methyl-1,2-dihydro- 1,2,4-benzotriozine (I) NC, P43 HZ, Roney-Ni Y 4 b I CH, dimethyl- 3-dimethylomino-7methyl- cyonomide 1,2,4-benzotriozine ... 5 2-8 8-0 MF: Cl,H,,N,O, MW: 366.41 EINECS: 20 0-1 5 6-1 LD,,: 9300 pglkg (M, i.v.); 1320 mglkg (M, p.0.); 1902 mgkg (R, p.0.) CN: endo-(f )-3 -( 3-hydroxy-l-oxo-2-...

Ngày tải lên: 02/07/2014, 02:20

... ylthio)methyl ]-5 -thia-l-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 7-orninocepholo- 4-mercopto- sporonic acid 1,Z.J-triozole 7(R)-omino- 3-[ (I ,2, 3- triozol-4-ylthio)methyl ]- 3-cephern-4-corboxylic ... RN: 5618 7-4 7-4 MF: C18H,5CI,N505S, MW: 548.45 CN: (6R-trans )-7 -[ [(3,5-dichloro-4-oxo-l(4H)-pyridinyl)acetyI]amino ]-3 -[ [(5-methyl-1,3,4-thiadiazol-...

Ngày tải lên: 02/07/2014, 02:20

... RN: 11 1 0-4 0-3 MF: C3,H3,N20s MW: 530.67 EINECS: 21 4-1 7 5-8 CN: (11~,16a )-2 1-( acetyloxy)-ll,17-dihydroxy-6,16-dimethyl-2'-phenyl-2'H-pregna-2,4,6-trieno[3, 2- clpyrazol-20-one Codeine ... 50 8-7 5-8 MF: C,H,,O,,, MW: 550 .65 EINECS: 20 8-0 8 6-3 LD,,,: 1 mglkg (M, i.v.); >2 glkg (M, p.0.); 15.2 mg/kg (R, i.v.) CN: (3~,5~ )-3 -[ (6-deoxy...

Ngày tải lên: 02/07/2014, 02:20

... 2-mothyl-5,6,7, 8- 4-methylbenzyl- 2-methyl-1 -( 4-methyl- tctrahydroisoquino- mognesium chloride benzyl )-1 .2.5.6.7, 8- linium bromide hexohydroisoquinoline (+ )-2 -methyl- 1-( 4- methylbenzy1 )- ... RN: 563 6-8 3-9 MF: C&,N2 MW: 292.43 EINECS: 22 7-0 834 LD,,: 27 mgkg (R, i.v.); 618 mgkg (R, p.0.); 45 mgkg (dog, i.v.) CN: N,N-dimethyl- 3-[ 1-(...

Ngày tải lên: 02/07/2014, 02:20

... 5294 2-3 1-1 MF: C,9H28CINS0 MW: 377.92 CN: 2-[ 3-[ 4-( 3-chlorophenyl )-1 -piperazinyl]propyl ]-4 ,5-diethyl-2,4-dihydro-3H-1,2,4-triazol-3-one 4,5-diethyl- 1 -bromo- 3- 2-( 3-chloropropyl )- b 5-1 ... chlarobenzayl )- 5-ethylthiophene CH3COOH, pyridine - H\ 1- \ phosphorus - NH2 (I) 5-( 2-ch1orophenyl )- (11) 1.3-dihydro- 7...

Ngày tải lên: 02/07/2014, 02:20

... 4-( 3-formylpropyl )- carbonyl)propyl ]- hydride 1 -( trimethylsilyl )- 1H-imidazale imidozole (111) 4-( tert-butyl- 4-[ 4-[ 4-( tert-butyl- carbamoy1 )-1 - carbomoyl)-phenyll- 4- bromobenzene hydroxybutyl ]-1 -( trimethyl- ... [5R-[3(R*),5a,6a(R*)] ]-6 -( l-tlydroxyethyl )-7 -oxo- 3-( tetrahydro-2-furmyl )-4 -thia-l-azabicyclo[3.2.O ]...

Ngày tải lên: 02/07/2014, 02:20

... per- 2-nitro-5-fluoro- mongonote fluorotoluene benzoic acid HOOC ethyl isocyanate- 0 CH3 ocetote potossium tert-butylate N-methyl- 7-fluoro-4-methyl- glycine 3,4-dihydro-2H-1. 4- benzodiazepin-2,5(1H )- ... 8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[l,5-a][1,4]be1uodiazepine-3-carhoxylic acid ethyl ester 1. Hz. Pd-C KMnO 2. COC12 F CH3 potassium F COOH 2....

Ngày tải lên: 02/07/2014, 02:20

... 2-[ [[ 1-( 4-chlorobenzoyl )-5 -methoxy-2-methyl-1H-indol-3-yl]acetyI]arnino ]-2 -deoxy-~-glucose indornetacin (9. v.) 1 -( 4-chlorobenzoyl )-2 - methyl-5-methoxyindol- 3-acetyl chloride (I) ... ethyl 2-( 2-methyl- 3.4.6-trifluorobenzayl )- 3-etho~yacr~late ethyl 2-( 2-methyl- 3.4.6-trifluorobenzoy1 )- 3-cyclopropylamino- acrylate (11) ethyl 1 -c...

Ngày tải lên: 02/07/2014, 02:20

... 35 mglkg (M, 1.v.) CN: 7-[ (aminoiminornethyl)aminol-N-[ 2-[ [ 4-[ (3-aminopropyl)arnino]butyl]arnino ]-1 -hydroxy- 2- 1 oxoelhyl]heptanamide S- (-) -form RN: 8493 7-4 5-1 MF: C,,H3,N70, . 3HC1 ... 10431 7-8 4-2 MF: C,,H3,N,O3 MW: 387.53 : $-( -) -base i RN: 8914 9-1 0-0 ME C,,H3,N70, MW: 387.53 R-(+)-base 1 RN: 11476 0-3 8-2 MF: C,,H,,N,O, M...

Ngày tải lên: 02/07/2014, 02:20

... RN: 13 5-0 9-1 MF: C,H,F3N304S, MW: 331.30 EINECS: 20 5-1 7 3-8 LD,,,: 750mg/kg(M,i.v.);>10g/kg(M,p.o.) CN: 3,4-dihydro- 6-( trifluoromethyl )-2 H-1,2,4-benzothiadiazine-7-sullunamide 1,1 -dioxide ... 432.56 EINECS: 23 7-0 9 3-4 LD,,: >3 glkg (M, p.0.); >3 glkg (R, p.0.) CN: (1 1 P )-1 1,21 -dihydroxy- 1 7-( I-oxobutoxy)pregn-4-ene-3,20-dione hydroco...

Ngày tải lên: 02/07/2014, 02:20

... [(7.8-difluoro- 3-methoxymethyl-2, 3- dihydro-4H-1.4-benz- oxozin-4-yl)methylene ]- molonote (IV) FS F LCH, 0 0 (?)-ethyl 9.10-difluoro- 3-hydroxymethyl- 7-0 ~ 0- 2,3-dihydro-7H-pyrido- [I ,2.3-de ]-1 .4-benzoxozine ... (R, p.0.) CN: (S )-9 -fluoro-2,3-dihydro-3-methy 1-1 0-( 4-~ nethy 1-1 -pipcraziny1 )-7 -oxo-7H-pyrido[1,2,3-de ]-1 , 4- benz...

Ngày tải lên: 02/07/2014, 02:20

... 2369 4-8 1-7 MF: C,,H22N20, MW: 262.35 EINECS: 24 5-8 3 1-1 CN: l-[(l-methylethyl)amino ]-3 -[ (2-methyl-1H-indol-4-yl)oxy ~-2 -propanol sulfate RN: 5639 6-9 4-2 MF: C3,H,N404 . H2S04 MW: 622.78 4-benzyloxyindole- 2- ... nitroonisole 2-methoxy- 6- nitrobenzyl bromide 2-rnethoxy- 6- nitrobenz- oldehyde (W) nitro- ethane 1 -( 2-methoxy- 6- 4-me...

Ngày tải lên: 02/07/2014, 02:20

... C,,H,,N,O,S MW: 3 11.36 EINECS: 25 6-6 2 7-7 4-amino-2.3-dimethyl- benzoldehyde 4-benzylidenomino-2.3-dimethyl- 1 -phenyl-5-A'-pyrozolone 1 -phenyl- 5-~ '-pyrazolone (I) (cf. ominophenozone ... [4S-(4a,4aa,5a,5ac1,12aa) ]-4 -( dimethyamino )- 1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a- pentahydroxy-6-methylene-l,l l -dioxo-2-naphthacenecarboxamide monohy...

Ngày tải lên: 02/07/2014, 02:20

... hexofluorophosphote H3C-0 2. HCI H3C-0 H3C-0 0, 0, CH3 CH3 methyl N-benzoyl- 3.4-dimethoxy-L- phenylolanine. 1. HCI H3C-0 2. + 0=CH2 r 11 H3C-0 2. benzyl olcohol (S )-2 -amino- 3-( 3, 4- dimethoxypheny1 )- ... acetate Cl / N, \ \ / methyl 2-bromo- benzoate (-) -0 -chlorodiisopinocarnpheylborane. THF b methyl 2-[ 3-[ 3-[ (2E )-( 7-chloro- qui...

Ngày tải lên: 02/07/2014, 02:20