... and NMR structure of human Bcl-xL, an inhibitor of programmed cell death. Nature 381, 335–341. 25 Suzuki M, Youle RJ & Tjandra N (2000) Structure of bax. Coregulation of dimer formation and ... peptides with the sequence of the first (a5) and second (a6) heli- ces of the Bax hairpin (Fig. 2) can independently reproduce important characteristics of the activity of th...
Ngày tải lên: 19/02/2014, 07:20
... allow evaluation of the T m . Charged states of Arg and ArgEE In order to understand the importance of amphiphilicity, titration curves of Arg and ArgEE were compared (Fig. 5 A). The pK a of amino groups ... presence of NaCl suggest that the molecular mechanism of ArgEE in preventing thermal inactivation and aggregation is different from that of Arg. Thermal unfolding...
Ngày tải lên: 19/02/2014, 16:20
Tài liệu Báo cáo khoa học: The undecided serpin The ins and outs of plasminogen activator inhibitor type 2 pdf
... minireview will focus on the cellular and molecular biology of PAI-2 and highlight some of the most recent findings on the role and impressive pattern of regulation of this enigmatic protease inhi- bitor. ... infection Cancer A number of in vivo studies have assessed the prognos- tic relevance of tumour- and stromal-derived PAI-2 in the metastatic spread of cancer of th...
Ngày tải lên: 20/02/2014, 02:21
Báo cáo khoa học: Evolutionary changes to transthyretin: structure and function of a transthyretin-like ancestral protein doc
... dublin TLP and zebrafish TLP are found in the flex- ible portions of strands B and C that protrude towards the solvent and in the conformation of the long loop connecting strands D and E [17]. ... present and discuss recent find- ings regarding the identification and distribution of TLP genes in nature, the structural and functional characterization of the TLP from various...
Ngày tải lên: 07/03/2014, 00:20
Báo cáo khoa học: Post-ischemic brain damage: pathophysiology and role of inflammatory mediators ppt
... Brain Research and Department of Neuroscience, ‘‘Tor Vergata’’ University, Rome, Italy 4 University Centre for Adaptive Disorders and Headache, Section of Neuropharmacology of Normal and Pathological ... levels of cytokines and chemokines enhance the expression of adhesion molecules on cerebral endothelial cells, facilitating the adhesion and transendothelial migration of...
Ngày tải lên: 07/03/2014, 03:20
Báo cáo khoa học: pH dependence, substrate specificity and inhibition of human kynurenine aminotransferase I ppt
... as lmolÆmin )1 Æmg )1 . Effect of buffer and pH on hKAT-I. To determine the effect of pH on hKAT-I activity, a buffer mixture consisting of 100 m M phosphate and 100 m M boric acid was prepared and the pH of the buffer ... Rate of KYNA production in the hKAT-I and kynurenine mixture in the presence of 2 m M of a-ketobutyrate and 2 m M of a diff erent a- keto acid. *P &...
Ngày tải lên: 07/03/2014, 16:20
Báo cáo khoa học: Intermodule cooperativity in the structure and dynamics of consecutive complement control modules in human C1r Structural biology docx
... HSQC spectra of CCP1CCP2 (#2) col- lected at 300 and 315 K at pH7.0. Fig. S12. Overlay of HSQC spectra collected at 300 K of single CCP1 and CCP2 and of pair of modules at neutral and acidic pH. Doc. ... mainly the b-strands. The loops between strands B and C, known as the ‘hypervariable loop‘, D and E, E and F, F and G, and G and H are particularly tolerant of...
Ngày tải lên: 15/03/2014, 23:20
Báo cáo khoa học: Cloning, over-expression, purification and characterization of Plasmodium falciparum enolase doc
... haracterization of r -Pfen. (A) Plot o f [2-PGA] vs. a ct ivity; and (B) plot of [PE P] vs. activity for the determ ination of K m .A5lL sample of enzyme containing 1.5 and 3.0 lg of r-Pfen , respect ... homology A B Fig. 5. Effect of univalent and bivalent cations on r-Pfen activity. (A) E ffect of NaCl (d)andKCl(s). Data are plotted as percentage activity vs. [salt]....
Ngày tải lên: 16/03/2014, 18:20
Báo cáo khoa học: Systems biology: model based evaluation and comparison of potential explanations for given biological data pot
... understanding of what the purpose of the analysis is. As we have stressed repeatedly, the purpose of a systems biology problem is generally differ- ent from that of a classical engineering and statistical problem, ... model- ing is often used to achieve a characterization of which of these mechanisms that are significantly active, and independently important, and which mech...
Ngày tải lên: 23/03/2014, 06:20