TOWARDS NEW THERAPIES FOR PARKINSON''''''''S DISEASE doc

... repertoire known for this enzyme. Rather than being involved in ethanol and retinol oxidation, Adh3 is mainly active towards glutathione-coupled formaldehydes [35], but also towards free hydroxyfatty acids ... defense towards alcohols and aldehydes, without generating toxic radicals, as is the case for the cytochrome P450 system [9]. Even though the ADHs are known to be involved in...

Ngày tải lên: 16/03/2014, 11:20

... provided exercise pro- gram and tasks performed. Patients commented that they felt comfortable during the home sessions and that they could foresee a need for such training in the future. This training ... impairments and thus reducing fall risk. Specific forms of exercise have been recommended as elements of fall-prevention programs for older adults, for example, aerobic-type exercises...

Ngày tải lên: 19/06/2014, 08:20

... (37°C) for 20 minutes followed by 4% paraformaldehyde (PFA) (4°C) for 10 minutes. Brains were removed, postfixed for 2 hours in PFA and then cryoprotected for 24 hours in PBS with 30% sucrose. Before ... Weidong Le* - wdle@sibs.ac.cn * Corresponding author Abstract Background: New strategies for the treatment of Parkinson's disease (PD) are shifted from dopamine (DA) repla...

Ngày tải lên: 18/06/2014, 15:20

... movements were recorded by the force platform and quantified by analyzing the variance of the torque induced towards the ground by the body movements. Val- ues were obtained for five periods: quiet ... values for indi- vidual variations in body constitution. For the posturogra- phy results, comparisons between DBS OFF and ON were done for each of the five time periods. This was cond...

Ngày tải lên: 19/06/2014, 08:20

... strategies, including newer drugs like beta-receptor blockers, for rate control in patients with chronic atrial fibrillation (Bjerregaard et al., 2004). Further, as new therapies for heart failure ... Pseudohypericin, Hyperforin) in St. John’s Wort (Hypericum perforatum L.) Hypericum, an extract of the flower of St. John’s wort, has been used for the treat- ment of depression for ce...

Ngày tải lên: 25/10/2013, 05:20

... PD patients, and therefore suggested changing the name of the disease from paralysis agitans (Latin for shaking palsy) to la maladie de Parkinson (French for Parkinson’s disease) . T-sub-type PD ... numerous therapies for other movement disorders with substantial impact on patients. While many therapies remain symptomatic, a number normalize the condition such as de-coppering in...

Ngày tải lên: 14/02/2014, 17:20

... Scale appeared be- fore the obligatory application of psycho- metric and clinimetric measures to clinical scaling, before sensitivity and specificity, before predictive values, before receiver oper- ating ... Parkin and defective ubiquitination in Parkinson’s disease 209 Heutink, P.: PINK-1 and DJ-1 – new genes for autosomal recessive Parkinson’s disease . . . 215 Whaley, N. R., Uitti,...

Ngày tải lên: 14/02/2014, 17:20

... fulfill the expectations for proteomics with respect to generating new hypotheses. Therefore, each element arising from the present study could represent a valuable starting-point for focused inves- tigations ... biology and oxidative stress in Parkinson disease pathogenesis. Nat Clin Pract Neurol 4, 600–609. 6 Lesage S & Brice A (2009) Parkinson’s disease: from monogenic forms to...

Ngày tải lên: 15/02/2014, 01:20