BREAST CANCER – CARCINOGENESIS, CELL GROWTH AND SIGNALING PATHWAYS ppt

... of Breast Cancer Cell Function 401 Irina S. Babina, Simona Donatello, Ivan R. Nabi and Ann M. Hopkins Breast Cancer – Carcinogenesis, Cell Growth and Signaling Pathways 34 including breast ... epidermal growth factor receptor (EGFR) is frequently associated with the development and progression of a number of human cancers, BREAST CANCER – CARCI...

Ngày tải lên: 27/06/2014, 17:20

... [43], and this molecule is known to bind to PECAM-1 [44]. These results suggest that cell cell junctions both sense and transmit local forces. Cell cell contact has been shown to both inhibit and stimulate ... to degree of cell cell contact. In this study, cell cell contact was controlled by cell micropatterning, so that a distinct number of cells could adhere in specific confi...

Ngày tải lên: 22/03/2014, 21:20

... in red). (B–D) Relative luciferase activity of pGL3m–ESR 1–3 ¢-UTR–WT (ESR 1–3 ¢-UTR–WT) and pGL3m–ESR 1–3 ¢-UTR–MUT (ESR 1–3 ¢-UTR–MUT) in HEK293T and MCF-7 cells cotransfected with pcDNA-3.0–miR-22 or ... pcDNA 3– miR-22 or pcDNA3.0) or duplexes (33 nm miR-22 duplex or control RNA duplex), 120 ng pGL3m–ESR 1–3 ¢-UTR–WT or pGL3m–ESR 1–3 ¢-UTR–MUT and 8 ng pRL-TK in trip-...

Ngày tải lên: 22/03/2014, 21:20

... 8% chance of developing breast cancer age 4 0–4 9 years, or − a 30% or greater lifetime risk of developing breast cancer. NICE clinical guideline 41 – Familial breast cancer 28 In some instances, ... grandparent, grandchild, aunt, uncle, niece and nephew; half sister and half brother. Third-degree relatives: great grandparent, great grandchild, great aunt, great...

Ngày tải lên: 15/03/2014, 00:20

... uPA –/ – Mammary gland 100 1.5 a 31 Lung, LN 3.5 [45,51,52] MMTV-PyMT; Plg –/ – Mammary gland 100 1.5 a 25 c Lung 3 MMTV-PyMT; VEGF Mammary gland 100 1–2 100 Lung 2 [91] MMTV-PyMT; MEKK1 –/ – Mammary gland 100 ... several signaling pathways, including signaling by Wnt family members [7], transforming growth factor-β (TGF-β) [8], insulin-like growth factor-I (IGF-I) [...

Ngày tải lên: 22/03/2014, 17:20

... Breast Cancer and Bone Health 1. Q: How can breast cancer affect bone health? A: Breast cancer can affect bone in two ways: ― Breast cancer can spread (metastasize) to bone. ― Breast ... the relationship between breast cancer and bone health: ― The relationship between breast cancer and bone health (page 2). ― The risk of breast cancer...

Ngày tải lên: 29/03/2014, 01:20

... system, cancer stem cells, cancer transient-amplifying (TA) cells and cancer differentiated cells, which is defined as verti- cal hierarchy here. Only cancer stem cells or cancer TA cells that ... Cancer stem cells are hierarchical populations that consist of precancerous stem cells, primary cancer stem cells, migrating cancer stem cells and chemoradioresistant cancer st...

Ngày tải lên: 18/06/2014, 19:20

... system, cancer stem cells, cancer transient-amplifying (TA) cells and cancer differentiated cells, which is defined as verti- cal hierarchy here. Only cancer stem cells or cancer TA cells that ... Cancer stem cells are hierarchical populations that consist of precancerous stem cells, primary cancer stem cells, migrating cancer stem cells and chemoradioresistant cancer st...

Ngày tải lên: 20/06/2014, 03:20

... prostate cancer stem cells. Cancer Res. 65, 1094 6–1 0951 (2005). 53. Sell, S. Cellular origin of cancer: dedifferentiation or stem cell maturation arrest? Environ. Health Perspect. 101, 1 5–2 6 (1993). 54. ... Horie-Inoue, K. & Inoue, S. Epigenetic and proteolytic inactivation of 1 4–3 -3sigma in breast and prostate cancers. Semin. Cancer Biol. 16, 23 5–2 39 (...

Ngày tải lên: 15/02/2014, 05:20