... has beeninvestigated since the 1960s. Poor solubility of a compoundhas been associated with incomplete, erratic, and/ or slowabsorption. Understanding aqueous solubility of potentialdrug candidates ... solutions, the size and shape of the solvents and solutes are always different and self-association and coassociation among the solvents and solutes always exist.In this case, the solubility ... HuDedicated to my grandmother Yunzhi Su,my parents Bailing Li and Jie Hu,my wife Xinghang, and my children Richard and Louisfor their unconditional love, encouragement, and understanding.—Xiaoling...