... group. Addition-ally, with both alendronate alone and in combination with calcitriol, total BMD (p = 0.005 and p = 0.047,respectively; Fig. 3) and cancellous BMD (p < 0.001 and p< 0.001, ... HK, Haskell WL, Marcus R, Ott SM, TornerJC, Quandt SA, Reiss TF, Ensrud KE: Randomised trial of effect of alendronate on risk of fracture in women with existing ver-tebral fractures. Lancet 1996, ... observed with alendronate alone. Therefore, no synergistic effects of alendronate and calcitriol were observed in terms of bonemass in OVX rats.In terms of the mechanical strength of the femoral...