... group 2 than in groups 1 and 5. The increase in cyto-solic cytochrome C content also suggested significantmitochondrial damage with cytochrome C release intothe cytosol in the myocardium of ... groups 3 and 4 than in group 5. In contrast, mRNA expressions ofIL-10 and eNOS, the anti-inflammatory indicators,were lowest in group 2 and significantly decreased ingroups 3 and 4 compared to that ... proposed to be immune-modulatory and anti-inflammatory through down-regulating bothinnate and adaptive immunity [13,34]. Additionally, sil-denafil has been found to possess anti-inflammatory,anti-fibroproliferative,...