... Thalcontis the percent injected dose of 18F-nifenein the brain regions of the control study, and Thalnicis the percent injected dose of 18F-nifene in the brainregions of the nicotine ... within the brain of the rat was18F-nifene. Aftersacrificing the rat, the brain was excised and dissectedinto the left and right hemispheres. Figure 3C,D shows the sagittal brain slices of the ... doses of injected nicotine. The displacement of 18F-nifene wasfound with the pre-nicotine challenges. With each doseincrease of nicotine, a steady increase in binding occu-pancy was found. The...