... average in-formation exchanged between the same var iables. Mutual in-formation is one of the pillars of Shannon information the- ory, and was introduced in the seminal paper by Shannon[16, 17].ACKNOWLEDGMENTS The ... Academy of Sciences of the United States of America, vol. 69, no. 1, pp. 4–6, 1972.[4] P. H. Sellers, On the theory and computation of evolution-ary distances,” SIAM Journal on Applied Mathematics, ... is the number of occurrences of the pair i, j in-side the aligned sequences. This equation weighs the log ratioassociated to the i, j entry of the BLOSUM matrix with the occurrences of the...