... IGF1R-transfectedGIST cell lines could also be used in vivo in suitable xeno-graft animal models to test the efficacy of different IGF1R-inhibitors and the effect of the combination with standardfront line therapies ... pathway inhibition byADW742, alone or in combination with imatinib, doxorubicin, orvincristine, is a novel therapeutic approach in Ewing tumor. Clin Cancer Res 2006, 12:3532-40.31. Kim WY, Jin ... great atten-tion should be paid to these clinical aspects and cautionexerted during therapeutic IGF1R inhibition in GIST.Conclusions In conclusion, a novel signali ng pathway other than KITand...