... receptors, such as the Epidermal Growth FactorReceptor (EGFR) and the Toll-like receptor, TLR4, havebeen shown to be dependent on Hrs, ESCRT-I and Vps4for their transport from early endosomes to ... machineryfunctions to sort cellular receptors into the lumen of the multivesicular body (MVB) prior to lysosomal degradation. ESCRT components can also be recruited by enveloped viruses to sites of viral ... important to prevent superinfection of the infected cell[61]. In addition, cross-linking of CD4 in the absence of Tcell receptor activation results in the generation of non-proliferative or apoptotic...