... biology and neuron-glia-neuron sig-naling and interactions, and thus test specific parts of the hypothesis. Neuroactive substances produced by, oraltered conditions related to, the production of ... Based on this literature and observations from ourown laboratory and others on the role of astroglial cells in the fine-tuning of glutamateneurotransmission we present the hypothesis that the ... C, Vaufrey F, Condé F, Chrétien F, Pichon J, Hantraye P, LeGrand R, Dormont D, Gras G: Up-regulation of glutamate con-centration in the putamen and in the prefrontal cortex of asymptomatic...