... comprises over 70% of the immune cells and represents the main reservoir and repli-cation site for HIV and other viruses). In addition, the sys-tem proposed includes the use of VLPs, which ... [23]. Under normalconditions the immune system prevents the formation ofself-reactive antibodies, and when they arise they are usu-ally transient. In fact, some of the broadly neutralizingantibodies ... overvalued and that byitself is not enough to break immune tolerance, illustrat-ing that these events are dose-dependent and requireother mechanisms, like bystander activation and anti-genic...