... tutorship and the editing of the man-uscript. KS and KO contributed to editing of the manuscript. MT and YU contributed to the conception,interpretation of results and the writing and editing of the manuscript. ... demyelination and alleviate the progression of disease and suppress TNFαproduction in twitcher brain. These results were consist-ent with the hypothesis that TNFα signaling enhancesapoptosis of OLs and ... which also suppressed the production of otherinflammatory mediators, such as nitric oxide (NO), IFN-γ, and IL-6, and enhanced the production of the inhibitorycytokine, IL-10, and neurotrophic factors,...