... grown in vitro under three-dimensional condi-tions using a mixture of collagen and fibroblasts [32,44].Interaction of a2andb1 integrins on CRC-specificT cells with collagen and the presence of ... cells), fixed in buffered formalin and embedded in paraffin. a, b: Staining with H&E. c, d: Specificbrown staining of apoptotic cells by anti-caspase 3 Ab. e, f: In situ end-labeling (ISEL); ... modulation of chemokine activ-ity at the tumor site could attract immune cells resulting in tumor growth inhibition (reviewed in [25] and [1]). In mo use systems, ex vivo transduction of chemokinesinto...