... Maruyama T, Nakanishi K,Shimada A, Uga M, Kurihara S, Kawabata Y, et al: Genetic associationbetween the interleukin-2 receptor-alpha gene and mode of onset oftype 1 diabetes in the Japanese ... IL-2-/- and IL-2b-/-mice, and was reduced compared to the C57BL/6 back-ground WT mice [48]. Altogether, these findings indi-cate that Jak3 and STAT 5a/ b signals are required tomaintain normal ... Candidate-geneapproaches have also demonstrated a role for the Idd3locu s in human celiac disease and RA [25], as well as in T1D [26,27]. Interestingly, neither the Idd3 locus, norany of the...