... (drain- ing sinus, pneumonia, etc.). Despite the retrospective design of our study and the limited possibility of in- terpreting these findings and their causes, this rate indicates that these ... procedure in the treatment of hip joint infec- tions over the past two decades. Depending on the definition of infection eradication and reinfection, hip spacers have repor...
Ngày tải lên: 26/10/2012, 09:53
... substrate carbinolamine intermediate; III, iminoquinone intermediate; IV, product Schiff base intermediate; V, aminoquinol intermediate. In the oxidative half-reaction the ami- noquinol intermediate ... kinetically in uential ionizations were identified in plots of k lim ⁄ K d of pK a values 7.1 and 9.3, again with the maximum value realized in the alkaline region. The pot...
Ngày tải lên: 19/02/2014, 07:20
Báo cáo khoa học: Adipocyte hyperplasia and RMI1 in the treatment of obesity doc
... of increased prolifera- tion or recruitment of preadipocytes [12], suggesting that these cyclin-dependent kinase inhibitors are important in the regulation of adipocyte number. The S-phase kinase-associated ... a deficiency in Skp2, the substrate-binding subunit of the SCF Skp2 complex, contributes to the degradation of p27 Kip1 , resulting in an induced resistance to...
Ngày tải lên: 06/03/2014, 01:20
Báo cáo khoa học: Nanoparticles can induce changes in the intracellular metabolism of lipids without compromising cellular viability docx
... modulate the expression of proteins involved in the retention of lipids in LDs, such as lip- ases or other LD-associated proteins. We have shown that at least one of these mechanisms is implicated in lipid ... storage in LDs. The PI3K ⁄ Akt signaling pathway stimulates lipogenesis via SREBP-1. FAS is the enzyme responsible for the synthesis of palmitate, the precur...
Ngày tải lên: 07/03/2014, 00:20
Báo cáo khoa học: C fi G base mutations in the CArG box of c-fos serum response element alter its bending flexibility Consequences for core-SRF recognition potx
... the point of view of enthalpy, but unfavored from the point of view of entropy. A 25 °C, the higher entropy of the linear form is likely due to its higher flexibility, the higher mobility of the ... cm )1 at 25 °C of about the same integral intensity, indicating a larger population of lin- ear conformers. The upshift and increase in intensity of the peak a...
Ngày tải lên: 07/03/2014, 09:20
Báo cáo khoa học: "PARSING VS. TEXT PROCESSING IN THE ANALYSIS OF DICTIONARY DEFINITIONS" pot
... passives inverted, inflected forms analyzed, and other modifications of the kind often brought under the rubric of "transformations." The LSP can do this sort of thing very welL The defining ... the node to the right of the taxonomy marker 'W") serving as a pointer to its own defining node. The resulting network is quite dense. We simplify by l...
Ngày tải lên: 08/03/2014, 18:20
Báo cáo khoa học: Post-translational modifications in the active site region of methyl-coenzyme M reductase from methanogenic and methanotrophic archaea potx
... described for the sulfuration of the C-terminal glycine in ThiS and MoaD, involved in thiamine biosynthesis and molyb- dopterin biosynthesis, respectively, and for the sulfura- tion of uridine in tRNA ... methylases [9]. How the sulfur is transferred into the carboxamide group of glycine in the peptide chain remains to be shown. Neither the functions of the five...
Ngày tải lên: 16/03/2014, 05:20
Báo cáo khoa học: Arginine-induced conformational change in the c-ring ⁄a-subunit interface of ATP synthase ppt
... arriving from the periplasm from escaping to the cytoplasm. In order to gain insight into the interaction of the stator arginine with the binding site, we modeled a stretch of seven amino acids of ... between the cNH group and the backbone oxygen of cV63, guiding the arginine side chain down- wards into the binding pocket. In Fig. 6C,D, two con- formations of a...
Ngày tải lên: 16/03/2014, 06:20
Báo cáo khoa học: Oxidative stress is involved in the permeabilization of the inner membrane of brain mitochondria exposed to hypoxia/reoxygenation and low micromolar Ca2+ Lorenz Schild1 and Georg Reiser2 doc
... degree of protection by ADP sug- gests that the mitochondrial injury is caused by open- ing of the mPTP. There is evidence that ADP inhibits opening of the mPTP by occupying binding sites located in ... reperfusion in brain. There is a growing body of information concerning the mechanism of ROS generation by the respiratory chain in mitochondria. Complex I and comple...
Ngày tải lên: 16/03/2014, 22:20
Báo cáo khoa học: Key substrate recognition residues in the active site of a plant cytochrome P450, CYP73A1 ppt
... residue in the initial binding and correct positioning of CA during catalysis. A role of N302 in anchoring the side-chain carboxylate of CA is further supported by the enhanced binding of amine substituted ligands ... mutagenesis of the involve- ment of some of these residues in the docking and catalysis of cinnamic acid. The impact of the active site mut...
Ngày tải lên: 17/03/2014, 10:20