... by interfering with the functions of E-cadherin and other cell adhesion molecules in MUC1 overexpressing breast can- cer cells [54-56]. In addition to this, mucins may also be involved in the invasion ... [22- 25]. All mucins share general characteristics. For example, they have repetitive domains of peptides rich in serine, threonine, and proline in their backbone. Serine and thre-...
Ngày tải lên: 20/06/2014, 07:20
... interest in Natural Language Processing, and in parsing in particular (e.g. (Koo and Collins, 2005; Matsuzaki et al., 2005; Riezler et al., 2002)). Latent variables provide a principled way to in- clude ... in- clude features in a probability model without need- ing to have data labeled with those features in ad- vance. Instead, a labeling with these features can be induced as p...
Ngày tải lên: 23/03/2014, 18:20
báo cáo hóa học:" Functional bracing for delayed union of a femur fracture associated with Paget''''s disease of the bone in an Asian patient: a case report" pot
... fractures in Paget's disease. Int Orthop 1999, 23:283-285. 12. Ramos L, Santos JA, Devesa F, Del Pino J: Interlocking nailing with the Seidel nail in fractures of the humeral diaphysis in Paget's ... accompanying images. A copy of the written consent is available for review by the Editor -in- Chief of this journal Competing interests The authors declare that they have no comp...
Ngày tải lên: 20/06/2014, 04:20
Báo cáo y học: "Advances in immunomodulating therapy of HBV infection"
... (1.25-5.68) respectively. Interestingly, an increase in virological response over time after the discontinuation of thymosin could be observed (p=0.02) [40]. The doses of thymosin α-1 in this meta-analysis ... E, Marinelli M, Tambussi G, Finazzi R et al. Hepatitis B surface antigen clearance and appearance of antibodies against hepatitis B surface after treatment with recombinant inter...
Ngày tải lên: 02/11/2012, 11:17
Báo cáo y học: "Advances in Molecular Diagnosis of HBV Infection and Drug Resistance"
... high intermediate low no LiPA 5% low low-intermediate yes intermediate low low yes Florescence nd intermediate intermediate no intermediate intermediate intermediate yes MALDI-TOF <5% intermediate ... resistance must now be seen within a broadening and evolving clinical context. Moreover, it is increasingly apparent that clinically relevant prediction and monitoring of viral resistance...
Ngày tải lên: 03/11/2012, 09:41
Tài liệu Báo cáo khoa học: Changes in purine specificity in tandem GAF chimeras from cyanobacterial cyaB1 adenylate cyclase and rat phosphodiesterase 2 pptx
... cGMP binding [13], and, in PDE6, both of the amino acids corresponding to Phe433 ⁄ Asp434 in rPDE2A are required for cGMP binding [14]. Our initial mutations in cyaB1 GAF B also involved individual ... major interaction site for the adenine moiety. In b1, an arginine residue (Ile417 in rPDE2) binds to N1 and a threonine (Ser419 in rPDE2) inter- acts with N7 and the N 6 amino group...
Ngày tải lên: 19/02/2014, 02:20
Tài liệu Báo cáo khóa học: Mutations in the hydrophobic core and in the protein–RNA interface affect the packing and stability of icosahedral viruses doc
... general unfolding, not leaving any hydrophobic cleft for bis-ANS binding. High pressure is well known to denature proteins to partially folded states [15,17,38,48–50]. The large increase in bis-ANS binding ... sterically interfere with side-chain packing in the protein’s interior. Mutations that create cavities in hydro- phobic environments generally cause proteins to become less stable...
Ngày tải lên: 19/02/2014, 12:20
Tài liệu Báo cáo khoa học: "Experiments in Semantic Classification" pptx
... a deepening of the lines be- tween the eyebrows, indicating concentration, deter- mination, opposition or hostility.” Definitions of this kind are again not easily handled in machine opera- ... adequate for our purposes. In giving a synonym definition, we are making use of a more general idea, namely, that of defining the intra- linguistic meaning of a word in terms of its relation...
Ngày tải lên: 19/02/2014, 19:20
Tài liệu Báo cáo khoa học: Histones in functional diversification Core histone variants pdf
... containing poly(ADP-ribose) polymerase activity and other single strand RNA viral proteins. They show structural similarity to the DNA binding domain of leucine aminopeptidases, suggesting that DNA ... interactions in both directions. An additional N-terminal sequence in CENP-A or the extra C-ter- minal region in mH2A both result in inactive and compact chromatin regions (Fig. 2G). I...
Ngày tải lên: 20/02/2014, 02:22
Tài liệu Báo cáo khoa học: Changes in rat liver mitochondria with aging Lon protease-like activity and N e-carboxymethyllysine accumulation in the matrix doc
... FUÆlgprotein )1 Æh )1 ). In parallel with this decrease in activity, oxidized proteins accumulated in the matrix upon aging while the CML-modified protein content assessed by ELISA significantly increased ... been found in several mammals including human tissues and cell lines [24–26]. It is responsible for the degradation of abnormal proteins and certain short-lived specific proteins [2...
Ngày tải lên: 20/02/2014, 11:20