... and the use of the abridgedMSLSS for the five life domains (rather than the use of single items for each of the life domains), resulted in greater sensitivity to detect these associations. In ... (e.g., the presence of disease) and symptom severity. Their “model of the deter-minants of quality of life (p. 448) is based on the proposi-tion that the life domains mediate the associationsbetween ... perspective of the individual, andare based on the general proposition that alterations in health status affect other conditions in life (life domains), such as physical and psychological function-ing,...