báo cáo hóa học:" Mapping of the Insomnia Severity Index and Other Sleep Measures to EuroQol EQ-5D Health State Utilities" ppt

... a mapping relationship between insomnia- related measures and the EQ-5D. We aimed to estimate the associations between the EQ-5D health state utilities and insomnia severity measures by mapping ... quantifying the impact of insomnia on patients’ health state utilities. To the best of our knowledge, the present study is the first to map an...

Ngày tải lên: 20/06/2014, 15:20

... study aimed to build a model to map from cardiac patients' demographic and outcome measures to the EQ- 5D index. The SAQ ECS was the strongest predictor of the EQ-5D index, and had the lowest ... respectively, and just under 30% of the variability was explained. The addition of the ECS scale of the SAQ to the model accounted for the great...

Ngày tải lên: 20/06/2014, 16:20

... of CHD severity with sex, the scales of the SAQ and CCS angina severity class and a smaller relationship with age and ETT. The variation seen in the relationship between the EQ-5D index and these ... more women to assess the robustness of the estimate of the relationship between sex and EQ-5D index in cardiac patients. Finally, we were not able...

Ngày tải lên: 18/06/2014, 19:20

... TST+/QFT- HCWs is unknown. A number of publications suggest it is low [9,27-29]. Because of the high sensitivity of the IGRA and the low specificity of the TST, none of the several national guidelines ... interpretation lead to a low sensitivity of the TST without reducing the specificity problems of the TST in a meaningful way. Therefore the use of the...

Ngày tải lên: 20/06/2014, 00:20

... as factory morpholo- gies of all clones; and all authors participated in writing the manuscript. MLN and KMC are the principal investi- gators and KMC determined the M1 sequences of the other ... identical to each other. Both show numerous regions of similarity to the hydropathy profile of the T2J µ2. However, there also are several distinct differences betwee...

Ngày tải lên: 20/06/2014, 04:20

... lateral face of the EED β-propeller. This groove slightly opened towards the lower face of the β- propeller (Fig. 3). The absence of overlapping of the MA and IN binding sites and the possible ... structure of the EED core was that most of the accessible surfaces should be confined to the outer β-strands d, and to flexible loops connecting β-strands of...

Ngày tải lên: 20/06/2014, 01:20

... binding. Measurements of the effects of Mab-1 or Mab-5 and neutralizers on the specific inhibitory activity of PAI-1 To measure the effects of antibodies and inactivators on the specific inhibitory activity of wt and ... Localization of the amino acids in the epitope for Mab-1. The structure shown is a ribbon representation of the coordinates of Stout et...

Ngày tải lên: 20/02/2014, 11:20

... cysteine-rich part. Further localization of the epitopes of 45M1, 2-12 M1 and 166M1 In order to further locate the epitopes of the hitherto unmapped 45M1, 2-12M1 and 166M1, these mAbs were screened ... of the C-terminal cysteine-rich part of MUC5AC, pre- sumably in the last CysD domain of the mucin. The epitope of 2-12M1 is located in the sequence corre- sp...

Ngày tải lên: 07/03/2014, 05:20

... phosphates P2, P4 and P9–13 lowered the k rel values by c. 50%. The replacement of 3mm Mg 2+ with 3 mm Mn 2+ resulted in a restoration of the activity to the level of the k Mn obs of the unmodified enzyme ... oxygen ligand at C6 of the subsequent guanosine nucleotide (Fig. 7). One can argue that in this model the distances between the oxygen ligands of P5 and...

Ngày tải lên: 07/03/2014, 10:20

... We therefore mutated Asp36 and Glu39 of CP12 into Ala or Lys. To test whether the interactions of these mutants with the other partner, GAPDH were im- paired, we tried to reconstitute in vitro the ... analogy with the CTE of the isoform of GAPDH [15,37], we hypothesize that the disulfide bridge at the C-terminus of CP12 might confer a conformation to CP12 that...

Ngày tải lên: 16/03/2014, 13:20