... in celldeath in CAVM1 cells. An intriguing mechanism, in thisregard, is the presence of scaffolding domain in caveolin-1 that binds to and inhibits the activity of several signalingproteins ... scaffolding domain. This leads, in turn, in inhibitionof proliferation and induction of HepG2 cell apoptosismediated through the p38MAPK pathway and caspase-3protein expression.Competing interestsThe ... signalingproteins in vitro and in situ, including the EGF and Neureceptors, Src-family kinases (Src/Fyn), PKCs, eNOS and the heterotrimeric G-proteins [32]. Thus, it remains to beexplained why over-expression...